Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.1.138 extracted from

  • Shimizu, M.; Tada, E.; Makiyama, T.; Yasufuku, K.; Moriyama, Y.; Fujino, H.; Nakamura, H.; Murayama, T.
    Effects of ceramide, ceramidase inhibition and expression of ceramide kinase on cytosolic phospholipase A2alpha; additional role of ceramide-1-phosphate in phosphorylation and Ca2+ signaling (2009), Cell. Signal., 21, 440-447.
    View publication on PubMed
Search for more literature for 2.7.1.138

Cloned(Commentary)

Cloned (Comment) Organism
expression of green fluorescent protein-tagged human ceramide kinase in CHO-W11A cells, the increase in ceramide 1-phosphate formation by transfection with the vector for human ceramide kinase significantly enhances the Ca2+-ionophore A23187-induced release of arachidonic acid via cytosolic phospholipase A2alpha activation in CHO cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
2,5-dihydroxy-3-[[(4aS,8aS)-2,5,5,8a-tetramethyl-3,4,4a,5,6,7,8,8a-octahydronaphthalen-1-yl]methyl]cyclohexa-2,5-diene-1,4-dione K1, novel F-12509A olefin isomer, inhibitor decreases ceramide 1-phosphate levels without changing other lipids such as ceramide and sphingomyelin Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
plasma membrane
-
 Homo sapiens 5886
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ ceramide kinase is Ca2+-dependent Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + ceramide Homo sapiens
-
 ADP + ceramide 1-phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + ceramide
-
 Homo sapiens ADP + ceramide 1-phosphate
-
 ?

Synonyms

Synonyms Comment Organism
ceramide kinase
-
 Homo sapiens
CERK
-
 Homo sapiens