Literature summary for 2.7.1.138 extracted from

Graf, C.; Zemann, B.; Rovina, P.; Urtz, N.; Schanzer, A.; Reuschel, R.; Mechtcheriakova, D.; Mueller, M.; Fischer, E.; Reichel, C.; Huber, S.; Dawson, J.; Meingassner, J.G.; Billich, A.; Niwa, S.; Badegruber, R.; Van Veldhoven, P.P.; Kinzel, B.; Baumruker, T.; Bornancin, F.
Neutropenia with impaired immune response to Streptococcus pneumoniae in ceramide kinase-deficient mice (2008), J. Immunol., 180, 3457-3466.

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Application

Application	Comment	Organism
medicine	ceramide kinase is important for neutrophil homeostasis, ceramide kinase is important for the defense against Streptococcus pneumoniae infections	Mus musculus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
Golgi apparatus	-	Mus musculus	5794	-

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Ca2+	-	Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ceramide + ATP	Mus musculus	ceramide kinase is not the only source of ceramide 1-phosphate, ceramide kinase is important for neutrophil homeostasis, ceramide kinase is important for the defense against Streptococcus pneumoniae infections	ceramide 1-phosphate + ADP	-	?

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
bone marrow	-	Mus musculus	-
leukocyte	-	Mus musculus	-
macrophage	bone marrow-derived macrophage, BMDM	Mus musculus	-
mast cell	bone marrow-derived mast cell	Mus musculus	-
neutrophil	-	Mus musculus	-
peritoneal macrophage	-	Mus musculus	-
spleen	-	Mus musculus	-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
0.000000004	-	liver of wild-type mice	Mus musculus
0.000000028	-	kidney of wild-type mice	Mus musculus
0.000000038	-	pancreas of wild-type mice	Mus musculus
0.000001191	-	testis of wild-type mice	Mus musculus
0.00000141	-	cerebellum of wild-type mice	Mus musculus

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ceramide + ATP	-	Mus musculus	ceramide 1-phosphate + ADP	-	?
ceramide + ATP	ceramide kinase is not the only source of ceramide 1-phosphate, ceramide kinase is important for neutrophil homeostasis, ceramide kinase is important for the defense against Streptococcus pneumoniae infections	Mus musculus	ceramide 1-phosphate + ADP	-	?
N-(7-(4-nitrobenzo-2-oxa-1,3-diazole))-6-aminocaproyl-D-erythrosphingosine + ATP	-	Mus musculus	N-(7-(4-nitrobenzo-2-oxa-1,3-diazole))-6-aminocaproyl-D-erythrosphingosine 1-phosphate + ADP	-	?

Synonyms

Synonyms	Comment	Organism
CERK	-	Mus musculus

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Release 2023.1 (January 2023)