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Literature summary for 2.7.1.138 extracted from

  • Munagala, N.; Nguyen, S.; Lam, W.; Lee, J.; Joly, A.; McMillan, K.; Zhang, W.
    Identification of small molecule ceramide kinase inhibitors using a homogeneous chemiluminescence high throughput assay (2007), Assay Drug Dev. Technol., 5, 65-74.
    View publication on PubMed

Application

Application Comment Organism
medicine potentially important therapeutic target in oncology and inflammation Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expression in baculovirus-infected SF9 insect cells Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.031
-
ATP
-
Homo sapiens
0.107
-
C12-ceramide
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ceramide + ATP Homo sapiens ceramide is a key mediator of cellular apoptosis ceramide 1-phosphate + ADP
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
nickel-nitriloacetate resin chromatography Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
C12-ceramide + ATP
-
Homo sapiens C12-ceramide 1-phosphate + ADP
-
?
ceramide + ATP
-
Homo sapiens ceramide 1-phosphate + ADP
-
?
ceramide + ATP ceramide is a key mediator of cellular apoptosis Homo sapiens ceramide 1-phosphate + ADP
-
?

Synonyms

Synonyms Comment Organism
CERK
-
Homo sapiens