Cloned (Comment) | Organism |
---|---|
stable expression of human CerK in COS-1 cell, named COS-CerK cell, and RBL-2H3 cell | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
NVP-231 | diamino-benzothiazole derivative, potent inhibitor, no inhibition with its analog NVP-995 | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ceramide + ATP | Homo sapiens | involvement in inflammatory processes and cell growth | ceramide 1-phosphate + ADP | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q8TCT0 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
C2-ceramide + ATP | C2-Cer is a potent inducer of cell death in CerK-expressing cells | Homo sapiens | C2-ceramide 1-phosphate + ADP | - |
? | |
ceramide + ATP | - |
Homo sapiens | ceramide 1-phosphate + ADP | - |
? | |
ceramide + ATP | involvement in inflammatory processes and cell growth | Homo sapiens | ceramide 1-phosphate + ADP | - |
? |
Synonyms | Comment | Organism |
---|---|---|
CERK | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000012 | - |
- |
Homo sapiens | NVP-231 |