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Literature summary for 2.7.1.138 extracted from

  • Mitsutake, S.; Kim, T.J.; Inagaki, Y.; Kato, M.; Yamashita, T.; Igarashi, Y.
    Ceramide kinase is a mediator of calcium-dependent degranulation in mast cells (2004), J. Biol. Chem., 279, 17570-17577.
    View publication on PubMed
Search for more literature for 2.7.1.138

Cloned(Commentary)

Cloned (Comment) Organism
stable expression in the cytosol and plasma membrane of rat basophilic leukemia RBL-2H3 cells, overexpression of the enzyme enhances the level of degranulation Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
N-acetylsphingosine i.e. C2-Cer, in vivo during inhibition of mast cell degranulation Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Mus musculus 5829
-
plasma membrane
-
 Mus musculus 5886
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ optimal activation at 1 mM, enzyme is a mediator of calcium-dependent degranulation in mast cells Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + ceramide Mus musculus
-
 ADP + ceramide 1-phosphate
-
 ?
additional information Mus musculus the enzyme is a mediator of calcium-dependent degranulation in mast cells ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + ceramide
-
 Mus musculus ADP + ceramide 1-phosphate
-
 ?
additional information the enzyme is a mediator of calcium-dependent degranulation in mast cells Mus musculus ?
-
 ?

Synonyms

Synonyms Comment Organism
CERK
-
 Mus musculus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
 assay at Mus musculus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Mus musculus