Inhibitors | Comment | Organism | Structure |
---|---|---|---|
3-Methyladenine | 3-MA, a nonspecific inhibitor of PI 3-kinases | Arabidopsis thaliana |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
endosome | late | Arabidopsis thaliana | 5768 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | required | Arabidopsis thaliana |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 1-phosphatidyl-1D-myo-inositol | Arabidopsis thaliana | - |
ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Arabidopsis thaliana | P42339 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
root | - |
Arabidopsis thaliana | - |
root tip | - |
Arabidopsis thaliana | - |
seed | - |
Arabidopsis thaliana | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 1-phosphatidyl-1D-myo-inositol | - |
Arabidopsis thaliana | ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
phosphatidylinositol 3-kinase | - |
Arabidopsis thaliana |
PI 3-kinase | - |
Arabidopsis thaliana |
vacuolar protein sorting 34 | - |
Arabidopsis thaliana |
VPS34 | - |
Arabidopsis thaliana |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Arabidopsis thaliana |
General Information | Comment | Organism |
---|---|---|
malfunction | Arabidopsis thaliana pollen development is abnormal in knockout mutants for shared components of two VPS34 complexes (VPS34, VPS15, and ATG6/VPS30) | Arabidopsis thaliana |
additional information | in yeast and mammals, Vps34 homologues are found in at least two distinct PI 3-kinase complexes. The Vps34 complex I, consisting of Vps34, Vps15, autophagy-related 6 (Atg6)/Vps30, and Atg14, regulates an early step of autophagy at the site of autophagosome formation, whereas the Vps34 complex II containing Vps34, Vps15, Atg6/ Vps30, and Vps38 (or UVRAG in mammals) is involved in vacuolar protein sorting and localized to the endosome | Arabidopsis thaliana |