Activating Compound | Comment | Organism | Structure |
---|---|---|---|
insulin-like growth factor-I | strongly stimulates insulin receptor substrate-1-associated phosphatidylinositol 3-kinase activity about 54fold and total phosphatidylinositol 3-kinase activity abozut 6fold | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
MCF-7 cell | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
PI 3-kinase | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | epidermal growth factor and fibroblast growth factor inhibit insulin-like growth factor-I-stimulated tyrosine phosphorylation of insulin receptor substrate-1 and the subsequent insulin-like growth factor-I-induced phosphatidylinositol 3-kinase activity. These epidermal growth factor and fibroblast growth factor inhibitory effects are dependent on both phosphatidylinositol 3-kinase and protein kinase D1 signaling pathways. Specific inhibition of either phosphatidylinositol 3-kinase or protein kinase D1 totally impairs epidermal growth factor- or fibroblast growth factor-induced inhibition of insulin-like growth factor-I-stimulated insulin receptor substrate-1 tyrosine phosphorylation. The negative regulation of IRS-1 requires the coordinated action of phosphatidylinositol 3-kinase and protein kinase D1 | Homo sapiens |