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Literature summary for 2.7.1.137 extracted from

  • Karam, M.; Lassarre, C.; Legay, C.; Ricort, J.M.
    Phosphatidylinositol 3-kinase and protein kinase D1 specifically cooperate to negatively regulate the insulin-like growth factor signaling pathway (2012), Biochim. Biophys. Acta, 1823, 558-569.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
insulin-like growth factor-I strongly stimulates insulin receptor substrate-1-associated phosphatidylinositol 3-kinase activity about 54fold and total phosphatidylinositol 3-kinase activity abozut 6fold Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
MCF-7 cell
-
Homo sapiens
-

Synonyms

Synonyms Comment Organism
PI 3-kinase
-
Homo sapiens

General Information

General Information Comment Organism
physiological function epidermal growth factor and fibroblast growth factor inhibit insulin-like growth factor-I-stimulated tyrosine phosphorylation of insulin receptor substrate-1 and the subsequent insulin-like growth factor-I-induced phosphatidylinositol 3-kinase activity. These epidermal growth factor and fibroblast growth factor inhibitory effects are dependent on both phosphatidylinositol 3-kinase and protein kinase D1 signaling pathways. Specific inhibition of either phosphatidylinositol 3-kinase or protein kinase D1 totally impairs epidermal growth factor- or fibroblast growth factor-induced inhibition of insulin-like growth factor-I-stimulated insulin receptor substrate-1 tyrosine phosphorylation. The negative regulation of IRS-1 requires the coordinated action of phosphatidylinositol 3-kinase and protein kinase D1 Homo sapiens