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Literature summary for 2.7.1.137 extracted from

  • Chan, G.; Bivins-Smith, E.R.; Smith, M.S.; Yurochko, A.D.
    NF-kappaB and phosphatidylinositol 3-kinase activity mediates the HCMV-induced atypical M1/M2 polarization of monocytes (2009), Virus Res., 144, 329-333.
    View publication on PubMedView publication on EuropePMC
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Inhibitors

Inhibitors Comment Organism Structure
LY294002
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
monocyte
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
PI3K
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function NF-kappaB and phosphatidylinositol 3-kinase activity mediate the human cytomegalovirus, HCMV, induced atypical M1/M2 polarization of monocytes, overview. PI3K activity is involved in the upregulation of about 12% of M1-associated genes following infection with HCMV. And the enzyme is involved increased motility of HCMV-infected native cells by about 5.5fold compared to uninfected cells treated with mock-infected cell supernatants Homo sapiens