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Literature summary for 2.7.1.137 extracted from

  • Scholl, S.; Bondeva, T.; Liu, Y.; Clement, J.H.; Hoeffken, K.; Wetzker, R.
    Additive effects of PI3-kinase and MAPK activities on NB4 cell granulocyte differentiation: potential role of phosphatidylinositol 3-kinase gamma (2008), J. Cancer Res. Clin. Oncol., 134, 861-872.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
LY294002
-
Homo sapiens
Wortmannin
-
Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + 1-phosphatidyl-1D-myo-inositol Homo sapiens
-
ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
granulocyte
-
Homo sapiens
-
NB-4 cell a promyelocytic leukemia cell line, expression of different PI3K isoforms during granulocyte differentiation of NB4 cells induced by all-trans-retinoic acid, 9-cis-retinoic acid or retinoic acid receptor agonists, overview Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 1-phosphatidyl-1D-myo-inositol
-
Homo sapiens ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
-
?

Synonyms

Synonyms Comment Organism
PI3-kinase
-
Homo sapiens
PI3K
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
assay at Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
Homo sapiens

General Information

General Information Comment Organism
malfunction Co-treatment of NB4 cells with either LY294002 to inhibit PI3Ks or PD98059 in order to suppress MEK activity lead to significant reduction of CD11b surface expression during all-trans-retinoic acid, 9-cis-retinoic acid or retinoic acid receptor agonist Ro40-6055 dependent NB4 cells granulocyte differentiation Homo sapiens
physiological function involvement of PI3K in all-trans-retinoic acid or Ro40-6055, a retinoic acid receptor alpha specific agonist, dependent granulocyte differentiation of NB4 cells, overview Homo sapiens