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Literature summary for 2.7.1.137 extracted from

  • Min, K.J.; Kim, J.H.; Jou, I.; Joe, E.H.
    Adenosine induces hemeoxygenase-1 expression in microglia through the activation of phosphatidylinositol 3-kinase and nuclear factor E2-related factor 2 (2008), Glia, 56, 1028-1037.
    View publication on PubMed
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Activating Compound

Activating Compound Comment Organism Structure
adenosine adenosine activates PI3K and induces Akt phosphorylation leading to induction of hemeoxygenase-1, HO-1, expression in microglia. Adenosine acts as an endogenous regulator of brain inflammation via modulation of microglial reactive oxygen species production, mechanism, overview Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
LY294002
-
 Rattus norvegicus
Wortmannin
-
 Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus activation of PI3K by adenosine leads to induction of hemeoxygenase-1, HO-1, expression in microglia ?
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
 Sprague Dawley rats
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Rattus norvegicus
-
microglia
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information activation of PI3K by adenosine leads to induction of hemeoxygenase-1, HO-1, expression in microglia Rattus norvegicus ?
-
 ?

Synonyms

Synonyms Comment Organism
PI3K
-
 Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Rattus norvegicus