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Literature summary for 2.7.1.137 extracted from
- Characteristic response of astrocytes to plasminogen/plasmin to upregulate transforming growth factor beta 3 (TGFbeta3) production/secretion through proteinase-activated receptor-1 (PAR-1) and the downstream phosphatidylinositol 3-kinase (PI3K)-Akt/PKB si (2009), Brain Res., 1305, 1-13.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| LY294002 | a specific inhibitor of PI3K, effectively suppresses the microglia-derived plasminogen-dependent phosphorylation of Akt | Rattus norvegicus |  |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | - |
Rattus norvegicus | 16020 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| astrocyte | - |
Rattus norvegicus | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| phosphatidylinositol 3 kinase | - |
Rattus norvegicus |
| PI3K | - |
Rattus norvegicus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Rattus norvegicus | |
General Information
| General Information | Comment | Organism |
|---|---|---|
| metabolism | phosphatidylinositol 3-kinase is closely associated with TGFbeta3 production/secretion in astrocytes. Microglia-derived plasminogen or plasmin facilitates the production/secretion of TGFbeta3 in astrocytes through both PAR-1 and the subsequent signaling cascade including PI3K and Akt | Rattus norvegicus |
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Release 2023.1 (January 2023)
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