Inhibitors | Comment | Organism | Structure |
---|---|---|---|
LY294002 | a specific inhibitor of PI3K, effectively suppresses the microglia-derived plasminogen-dependent phosphorylation of Akt | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | - |
Rattus norvegicus | 16020 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
astrocyte | - |
Rattus norvegicus | - |
Synonyms | Comment | Organism |
---|---|---|
phosphatidylinositol 3 kinase | - |
Rattus norvegicus |
PI3K | - |
Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Rattus norvegicus |
General Information | Comment | Organism |
---|---|---|
metabolism | phosphatidylinositol 3-kinase is closely associated with TGFbeta3 production/secretion in astrocytes. Microglia-derived plasminogen or plasmin facilitates the production/secretion of TGFbeta3 in astrocytes through both PAR-1 and the subsequent signaling cascade including PI3K and Akt | Rattus norvegicus |