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Literature summary for 2.7.1.137 extracted from
- The diabetogenic effects of excessive ethanol: reducing beta-cell mass, decreasing phosphatidylinositol 3-kinase activity and GLUT-4 expression in rats (2009), Br. J. Nutr., 101, 1467-1473.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| Insulin | stimulates PI3K activity | Rattus norvegicus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| ethanol | dose-dependent inhibition of insulin receptor substrate-1-associated PI3K activity in skeletal muscle, but not in adipose tissue, ethanol-induced diabetic rats | Rattus norvegicus |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
Wistar rats | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| adipose tissue | - |
Rattus norvegicus | - |
| skeletal muscle | - |
Rattus norvegicus | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| PI3K | - |
Rattus norvegicus |
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Release 2023.1 (January 2023)
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