Activating Compound | Comment | Organism | Structure |
---|---|---|---|
morphine | morphine treatment enhances the level of phosphorylated, rather than unphosphorylated, PI3K and AKT, which are synchronously recruited to membrane. Levels of PTEN and p53, which are negative regulators of these signal molecules, are reduced, and as a result, the interaction between PTEN and p53 is completely interrupted | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
LY294002 | i.e. [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] | Homo sapiens | |
naloxone | - |
Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | - |
Homo sapiens | 16020 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
B-lymphocyte | - |
Homo sapiens | - |
T-lymphocyte | - |
Homo sapiens | - |
Subunits | Comment | Organism |
---|---|---|
heterodimer | PI3K is a heterodimer composed of a p85 regulatory subunit and a p110 catalytic subunit | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
PI3K | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | role of PI3K/AKT signaling in expression of the MOR gene in CEM x 174 cells. Phosphatidylinositol 3-kinase pathway mediated up-regulation of the mu opioid receptor in lymphocytes, mechanisms, overview | Homo sapiens |