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Literature summary for 2.7.1.137 extracted from

  • Lee, S.A.; Park, S.H.; Kim, B.C.
    Raloxifene, a selective estrogen receptor modulator, inhibits lipopolysaccharide-induced nitric oxide production by inhibiting the phosphatidylinositol 3-kinase/Akt/nuclear factor-kappa B pathway in RAW264.7 macrophage cells (2008), Mol. Cells, 26, 48-52.
    View publication on PubMed
Search for more literature for 2.7.1.137

Inhibitors

Inhibitors Comment Organism Structure
LY294002
-
 Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus raloxifene exerts its anti-inflammatory action in LPS-stimulated macrophages by blocking the PI 3-kinase-Akt-NF-kappaB signaling cascade, and eventually reduces expression of pro-inflammatory genes such as the nitric oxide synthase gene ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
RAW-264.7 cell
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information raloxifene exerts its anti-inflammatory action in LPS-stimulated macrophages by blocking the PI 3-kinase-Akt-NF-kappaB signaling cascade, and eventually reduces expression of pro-inflammatory genes such as the nitric oxide synthase gene Mus musculus ?
-
 ?

Synonyms

Synonyms Comment Organism
PI 3-kinase
-
 Mus musculus