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Literature summary for 2.7.1.137 extracted from

  • Berggren, M.I.; Gallegos, A.; Dressler, L.A.; Modest, E.J.; Powis, G.
    Inhibition of the signalling enzyme phosphatidylinositol-3-kinase by antitumor ether lipid analogs (1993), Cancer Res., 53, 4297-4302.
    View publication on PubMed
Search for more literature for 2.7.1.137

Inhibitors

Inhibitors Comment Organism Structure
(+/-)-2-[hydroxy[tetrahydro-2-(octadecyloxy)methylfuran-2-yl]methoxyl]phosphinyloxy-N,N,N-trimethylethaniminium hydroxide
-
 Bos taurus
(+/-)-2-[hydroxy[tetrahydro-2-(octadecyloxy)methylfuran-2-yl]methoxyl]phosphinyloxy-N,N,N-trimethylethaniminium hydroxide
-
 Mus musculus
1-O-octadecyl-2-O-methyl-rac-3-glycerophospho-myo-inositol
-
 Bos taurus
1-O-octadecyl-2-O-methyl-rac-3-glycerophospho-myo-inositol
-
 Mus musculus
1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphocholine noncompetitive with ATP Bos taurus
1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphocholine noncompetitive with ATP Mus musculus
hexadecylphosphocholine
-
 Bos taurus
hexadecylphosphocholine
-
 Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus enzyme might contribute to the antiproliferative activity of the antitumor ether lipid analogs ?
-
 ?
additional information Bos taurus enzyme might contribute to the antiproliferative activity of the antitumor ether lipid analogs ?
-
 ?

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Bos taurus
-
cell culture Swiss 3T3 fibroblast Mus musculus
-
fibroblast Swiss 3T3 fibroblast Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 1-O-octadecyl-2-O-methyl-rac-3-glycerophospho-myo-inositol
-
 Mus musculus ADP + ?
-
 ?
ATP + 1-O-octadecyl-2-O-methyl-rac-3-glycerophospho-myo-inositol
-
 Bos taurus ADP + ?
-
 ?
ATP + 1-phosphatidylinositol
-
 Mus musculus ADP + phosphatidylinositol 3-phosphate
-
 ?
ATP + 1-phosphatidylinositol
-
 Bos taurus ADP + phosphatidylinositol 3-phosphate
-
 ?
additional information enzyme might contribute to the antiproliferative activity of the antitumor ether lipid analogs Mus musculus ?
-
 ?
additional information enzyme might contribute to the antiproliferative activity of the antitumor ether lipid analogs Bos taurus ?
-
 ?