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Literature summary for 2.7.1.137 extracted from

  • Arcaro, A.; Zvelebil, M.J.; Wallasch, C.; Ullrich, A.; Waterfield, M.D.; Domin, J.
    Class II phosphoinositide 3-kinases are downstream targets of activated polypeptide growth factor receptors (2000), Mol. Cell. Biol., 20, 3817-3830.
    View publication on PubMedView publication on EuropePMC
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Inhibitors

Inhibitors Comment Organism Structure
Wortmannin PI3K-C2a is refractory to Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ essential divalent cation in lipid kinase assays Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens class II PI3K enzymes may contribute to the generation of 3'-phosphoinositides following the activation of polypeptide growth factor receptors in vivo and thus mediate certain aspects of their biological activity ?
-
 ?
additional information Homo sapiens PI3K-C2alpha class II PI3K enzymes may contribute to the generation of 3'-phosphoinositides following the activation of polypeptide growth factor receptors in vivo and thus mediate certain aspects of their biological activity ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 enzyme form PI3K-C2a and PI3K-C2b
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Source Tissue

Source Tissue Comment Organism Textmining
cell culture carcinoma-derived A431 cells Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 1-phosphatidylinositol
-
 Homo sapiens ADP + phosphatidylinositol 3-phosphate
-
 ?
ATP + 1-phosphatidylinositol
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 Homo sapiens PI3K-C2alpha ADP + phosphatidylinositol 3-phosphate
-
 ?
additional information class II PI3K enzymes may contribute to the generation of 3'-phosphoinositides following the activation of polypeptide growth factor receptors in vivo and thus mediate certain aspects of their biological activity Homo sapiens ?
-
 ?
additional information class II PI3K enzymes may contribute to the generation of 3'-phosphoinositides following the activation of polypeptide growth factor receptors in vivo and thus mediate certain aspects of their biological activity Homo sapiens PI3K-C2alpha ?
-
 ?