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Literature summary for 2.7.1.137 extracted from

  • Hiles, I.D.; Otsu, M.; Volinia, S.; Fry, M.J.; Gout, I.; Dhand, R.; Panayotou, G.; Ruiz-Larrea, F.; Thompson, A.; Totty, N.F.; Hsuan, J.J.; Courtneidge, S.A.; Parker, P.J.; Waterfield, M.D.
    Phosphatidylinositol 3-kinase: structure and expression of the 110 kd catalytic subunit (1992), Cell, 70, 419-429.
    View publication on PubMed
Search for more literature for 2.7.1.137

Cloned(Commentary)

Cloned (Comment) Organism
expression of the 110000 Da subunit in Sf9 insect cells and in COS-1 cells Bos taurus
p110 expressed in insect cells possesses Pl3-kinase activity and associates with p85 alpha into an active p85 alpha-p110 complex that binds the activated colony-stimulating factor 1 receptor. p110 expressed in COS-1 cells is catalytically active only when complexed with p85 alpha Bos taurus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
85000
-
 1 * 85000 + 1 * 110000 Bos taurus
85000
-
 1 * 85000 + 1 * 124000, deduced from nucleotide sequence Bos taurus
110000
-
 1 * 85000 + 1 * 110000 Bos taurus
124000
-
 1 * 85000 + 1 * 124000, deduced from nucleotide sequence Bos taurus

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-
Bos taurus P32871
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 1-phosphatidylinositol
-
 Bos taurus ADP + phosphatidylinositol 3-phosphate
-
 ?

Subunits

Subunits Comment Organism
dimer 1 * 85000 + 1 * 110000 Bos taurus
dimer 1 * 85000 + 1 * 124000, deduced from nucleotide sequence Bos taurus