Literature summary for 2.7.1.136 extracted from

Noguchi, N.; Takada, K.; Katayama, J.; Emura, A.; Sasatsu, M.
Regulation of transcription of the mph(A) gene for macrolide 2'-phosphotransferase I in Escherichia coli: characterization of the regulatory gene mphR(A) (2000), J. Bacteriol., 182, 5052-5058.

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Cloned(Commentary)

Cloned (Comment)	Organism
mphA gene is arranged in close proximity to mrx and MphR(A) which are proteins probably involved in mph regulation, they all form a gene cluster	Escherichia coli

Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	1 mM p-chloromercuribenzoic acid or urea are no inhibitors, MphR(A) is a repressor protein that binds to the promoter of the mph(A) gene and negatively regulates the enzyme expression	Escherichia coli

Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	Q47396	macrolide 2'-phosphotransferase type I, high levels of activity with 14-member ring macrolides and extremely low levels with 16-member ring macrolides, accession code corresponds to nucleotide sequence for several proteins	-

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Release 2023.1 (January 2023)