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Literature summary for 2.7.1.127 extracted from

  • Chung, S.; Kim, I.H.; Lee, D.; Park, K.; Kim, J.Y.; Lee, Y.K.; Kim, E.J.; Lee, H.W.; Choi, J.S.; Son, G.H.; Sun, W.; Shin, K.S.; Kim, H.
    The role of inositol 1,4,5-trisphosphate 3-kinase A in regulating emotional behavior and amygdala function (2016), Sci. Rep., 6, 23757 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.1.127

Cloned(Commentary)

Cloned (Comment) Organism
gene Itpka, quantitative reverse transcription-PCR enzyme expression analysis Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information generation of IP3K-A KO mice and electrophysiological properties of IP3K-A KO mice, overview. No significant differences in basic electrophysiological properties between groups, such as resting membrane potential and input resistance is found. But the input-output functions of CeL neurons are significantly attenuated along with a longer latency to the first spike in KO mice Mus musculus

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + 1D-myo-inositol 1,4,5-trisphosphate Mus musculus
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 ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
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 ?
ATP + 1D-myo-inositol 1,4,5-trisphosphate Mus musculus C57BL/6N
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 ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
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 ?

Organism

Organism UniProt Comment Textmining
Mus musculus Q8R071
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Mus musculus C57BL/6N Q8R071
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-

Source Tissue

Source Tissue Comment Organism Textmining
amygdala IP3K-A expression is highly enriched in the central nucleus of the amygdala (CeA), which plays a pivotal role in the processing and expression of emotional phenotypes in mammals. P3K-A is primarily expressed in neurons rather than glia in the amygdala. In the CeA, IP3K-A primarily colocalizes with GAD67-positive GABAergic interneurons, whereas most IP3K-A in the BLA is in CAMKIIalpha-positive excitatory pyramidal neurons Mus musculus
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brain
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 Mus musculus
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forebrain
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 Mus musculus
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neuron in the CeA, IP3K-A primarily colocalizes with GAD67-positive GABAergic interneurons, whereas most IP3K-A in the BLA is in CAMKIIalpha-positive excitatory pyramidal neurons Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 1D-myo-inositol 1,4,5-trisphosphate
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 Mus musculus ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
 ?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
-
 Mus musculus C57BL/6N ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
 ?

Synonyms

Synonyms Comment Organism
inositol 1,4,5-trisphosphate 3-kinase A
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 Mus musculus
IP3K-A
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 Mus musculus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Mus musculus

General Information

General Information Comment Organism
malfunction genetic abrogation of IP3K-A alters amygdala gene expression, particularly in genes involved in key intracellular signaling pathways and genes mediating fear- and anxiety-related behaviors. In agreement with the changes in amygdala gene expression profiles, IP3K-A knockout (KO) mice display more robust responses to aversive stimuli and spent less time in the open arms of the elevated plus maze, indicating high levels of innate fear and anxiety. Decreased excitatory and inhibitory postsynaptic current and reduced c-Fos immunoreactivity are found in the CeA of IP3K-A KO mice Mus musculus
physiological function inositol 1,4,5-trisphosphate 3-kinase A (IP3K-A) is enriched in the brain and neurons that regulates intracellular calcium levels via signaling through the inositol trisphosphate receptor. IP3K-A expression is highly enriched in the central nucleus of the amygdala (CeA), which plays a pivotal role in the processing and expression of emotional phenotypes in mammals. IP3K-A has a profound influence on the basal activities of fear- and anxiety-mediating amygdala circuitry. IP3K-A plays an important role in regulating affective states by modulating metabotropic receptor signaling pathways and neural activity in the amygdala Mus musculus