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Literature summary for 2.7.1.127 extracted from

  • Blechner, C.; Becker, L.; Fuchs, H.; Rathkolb, B.; Prehn, C.; Adler, T.; Calzada-Wack, J.; Garrett, L.; Gailus-Durner, V.; Morellini, F.; Conrad, S.; Hoelter, S.M.; Wolf, E.; Klopstock, T.; Adamski, J.; Busch, D.; de Angelis, M.H.; Schmeisser, M.J.; Windhorst, S.
    Physiological relevance of the neuronal isoform of inositol-1,4,5-trisphosphate 3-kinases in mice (2020), Neurosci. Lett., 735, 135206 .
    View publication on PubMed
Search for more literature for 2.7.1.127

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + 1D-myo-inositol 1,4,5-trisphosphate Mus musculus
-
 ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus Q8R071
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain ITPKA is mainly expressed in pyramidal cells of the hippocampal CA1 region and granule cells of the dentate gyrus Mus musculus
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Caco-2 cell
-
 Mus musculus
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carcinoma cell
-
 Mus musculus
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central nervous system
-
 Mus musculus
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dentate gyrus
-
 Mus musculus
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granule cell
-
 Mus musculus
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hippocampus
-
 Mus musculus
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lung cancer cell
-
 Mus musculus
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additional information isozyme ITPKA is mainly expressed in neurons of the central nervous system and is also overexpressed in tumor cells Mus musculus
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neuron in mature neurons, ITPKA accumulates at postsynaptic densities (PSDs), where the protein is bound to F-actin Mus musculus
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pyramidal neuron
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 1D-myo-inositol 1,4,5-trisphosphate
-
 Mus musculus ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
 ?

Synonyms

Synonyms Comment Organism
inositol-1,4,5-trisphosphate 3-kinase
-
 Mus musculus
InsP3Kinase
-
 Mus musculus
ITPKA
-
 Mus musculus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Mus musculus

General Information

General Information Comment Organism
malfunction Itpka-deficient mice exhibit a weak metabolic phenotype, in keeping with functional studies revealing no clear role of ITPKA in metabolic organs. Broad phenotypic screening of itpka-deficient mice, Effects of itpka deficiency on brain function, overview. Among the neurobehavioral tests analyzed, itpka-deficient mice reacted faster to a hot plate, prepulse inhibition is impaired and the accelerating rotarod test shows decreased latency of itpka deficient mice to fall. Analysis of extracerebral functions in control and itpka deficient mice reveals significantly reduced glucose, lactate, and triglyceride plasma concentrations in itpka-deficient mice. Itpka deficiency affects energy metabolism, phenotype. Reduced glucose level is measured in plasma of itpka-deficient mice Mus musculus
physiological function isozyme ITPKA is involved in the regulation of nociceptive pathways, sensorimotor gating, and motor learning. Inositol-1,4,5-trisphosphate 3-kinase-A (ITPKA) is the neuronal isoform of ITPKs and exhibits both actin bundling and InsP3 kinase activity. In addition to neurons, ITPKA is ectopically expressed in tumor cells, where its oncogenic activity increases tumor cell malignancy. ITPKA is involved in the regulation of nociceptive pathways, sensorimotor gating and motor learning. ITPKA plays a functional role in calcium signaling of CaCo-2 cells Mus musculus