Literature summary for 2.7.1.127 extracted from

Franco-Echevarria, E.; Banos-Sanz, J.I.; Monterroso, B.; Round, A.; Sanz-Aparicio, J.; Gonzalez, B.
A new calmodulin-binding motif for inositol 1,4,5-trisphosphate 3-kinase regulation (2014), Biochem. J., 463, 319-328.

Search for more literature for 2.7.1.127

Activating Compound

Activating Compound	Comment	Organism	Structure
Calmodulin	the enzyme is activated by Ca2+/calmodulin. The human isozyme IP3-3K A contains a CaM binding domain at residues 158-183, binding structure and identification all of the key residues involved in the interaction, overview	Homo sapiens

Crystallization (Commentary)

Crystallization (Comment)	Organism
crystal structure of the complex between human Ca2+/CaM and the CaM-binding region of human IP3-3K isoform A (residues 158-183), modeling of the complex including the kinase domain	Homo sapiens

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Ca2+	the enzyme is activated by Ca2+/calmodulin	Homo sapiens
Mg2+	required	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + 1D-myo-inositol 1,4,5-trisphosphate	Homo sapiens	-	ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P23677	isozyme/gene ITPKA	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + 1D-myo-inositol 1,4,5-trisphosphate	-	Homo sapiens	ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate	-	?

Synonyms

Synonyms	Comment	Organism
ITPKA	-	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
ATP	-	Homo sapiens

General Information

General Information	Comment	Organism
physiological function	1D-myo-inositol 1,4,5-trisphosphate is a key point in Ca2+ metabolism that promotes Ca2+ release from intracellular stores and together with 1D-myo-inositol 1,3,4,5-tetrakisphosphate regulates Ca2+ homoeostasis. In addition, 1D-myo-inositol 1,3,4,5-tetrakisphosphate is involved in immune cell development. Ca2+ and calmodulin regulate the activity of inositol(1,4,5)trisphosphate 3-kinases via direct interaction	Homo sapiens

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Release 2023.1 (January 2023)