Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.1.127 extracted from

  • Pouillon, V.; Maréchal, Y.; Frippiat, C.; Erneux, C.; Schurmans, S.
    Inositol 1,4,5-trisphosphate 3-kinase B (Itpkb) controls survival, proliferation and cytokine production in mouse peripheral T cells (2013), Adv. Biol. Regul., 53, 39-50.
No PubMed abstract available
Search for more literature for 2.7.1.127

Protein Variants

Protein Variants Comment Organism
additional information construction of Itpkb-/- mice transgenically expressing Itpkb in thymocytes, tese mutant mice have some peripheral T cells left. The mutant mice shows partial rescue of T cell lineage development through recombinant expression of HA-tagged isozyme Itpkb in thymocytes Mus musculus

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ the enzyme is highly activated by Ca2+/calmodulin Mus musculus
Mg2+ required Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + 1D-myo-inositol 1,4,5-trisphosphate Mus musculus
-
 ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus B2RXC2 gene Itpkb
-

Source Tissue

Source Tissue Comment Organism Textmining
B-lymphocyte
-
 Mus musculus
-
mast cell
-
 Mus musculus
-
additional information ubiquitous tissue expression of isozyme Itpkb, the Itpkb protein contributes mainly to the majority of the Ins(1,4,5)P3 3-kinase activity in resting T and B lymphocytes as well as in neutrophils and mast cells Mus musculus
-
neutrophil
-
 Mus musculus
-
spleen
-
 Mus musculus
-
T-cell
-
 Mus musculus
-
T-lymphocyte
-
 Mus musculus
-
thymocyte
-
 Mus musculus
-
thymus
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 1D-myo-inositol 1,4,5-trisphosphate
-
 Mus musculus ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
 ?

Synonyms

Synonyms Comment Organism
inositol 1,4,5-trisphosphate 3-kinase B
-
 Mus musculus
Itpkb
-
 Mus musculus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Mus musculus

General Information

General Information Comment Organism
malfunction mice genetically-deficient for the B isoform of the inositol 1,4,5-trisphosphate 3-kinase have a severe defect in thymocytes differentiation and thus lack peripheral T cells. Mutant T cells show an increased activated/memory phenotype as well as a decreased proliferative capacity and survival, Itpkb-deficient peripheral T cells have also an increased capacity to secrete cytokines upon stimulation Mus musculus
physiological function functional role of isozyme Itpkb in peripheral T cells, potential role for Itpkb in autoimmunity Mus musculus