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Literature summary for 2.7.1.127 extracted from

  • Schell, M.J.; Erneux, C.; Irvine, R.F.
    Inositol 1,4,5-trisphosphate 3-kinase A associates with F-actin and dendritic spines via its N terminus (2001), J. Biol. Chem., 276, 37537-37546.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
CaM kinase II endogenous activator of isoform A Rattus norvegicus

Cloned(Commentary)

Cloned (Comment) Organism
full-length and truncated isoenzyme A is cloned and expressed in HeLa cells, COS-7 cells and primary neuronal cultures Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
actin filament recombinant isoenzyme A has an N-terminal 66-amino acid F-actin-binding region, isoform A co-localizes with F-actin Rattus norvegicus 5884
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cytoskeleton recombinant isoenzyme A associates with the cytoskeleton, targeting of IP3kin A to the actin cytoskeleton in transfected HeLa and COS-7 cells Rattus norvegicus 5856
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dendrite recombinant isoenzyme A has an N-terminal 66-amino acid F-actin-binding region that localizes the kinase to dentritic spines, endogenous isoenzyme A is localized to the dentritic spines of pyramidal neurons in primary hippocampal cultures Rattus norvegicus 30425
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plasma membrane recombinant isoenzyme A associates with Rattus norvegicus 5886
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + 1D-myo-inositol 1,4,5-trisphosphate Rattus norvegicus phosphorylation of IP3 in dentritic spines to produce IP4 is important for modulating the compartmentalization of calcium at synapses, control of calcium signals, the rapid, localized synthesis of IP4 may have complex effects on cytosolic calcium and on the molecular mechanisms that control learning and memory ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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isoenzyme A
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Source Tissue

Source Tissue Comment Organism Textmining
astrocyte highest expression of recombinant isoenzyme A in astrocytes of hippocampal cultures transfected with isoenzyme A Rattus norvegicus
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brain isoform A Rattus norvegicus
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hippocampus endogenous isoenzyme A is localized to the dentritic spines of pyramidal neurons in primary hippocampal cultures from neonatal rats, highest expression of recombinant isoenzyme A in astrocytes Rattus norvegicus
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neuron endogenous isoenzyme A is localized to the dentritic spines of pyramidal neurons in primary hippocampal cultures Rattus norvegicus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 1D-myo-inositol 1,4,5-trisphosphate isoform A: N-terminal 66-amino acid F-actin-binding region Rattus norvegicus ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate phosphorylation of IP3 in dentritic spines to produce IP4 is important for modulating the compartmentalization of calcium at synapses, control of calcium signals, the rapid, localized synthesis of IP4 may have complex effects on cytosolic calcium and on the molecular mechanisms that control learning and memory Rattus norvegicus ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
?

Cofactor

Cofactor Comment Organism Structure
ATP
-
Rattus norvegicus