Activating Compound | Comment | Organism | Structure |
---|---|---|---|
CaM kinase II | endogenous activator of isoform A | Rattus norvegicus |
Cloned (Comment) | Organism |
---|---|
full-length and truncated isoenzyme A is cloned and expressed in HeLa cells, COS-7 cells and primary neuronal cultures | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
actin filament | recombinant isoenzyme A has an N-terminal 66-amino acid F-actin-binding region, isoform A co-localizes with F-actin | Rattus norvegicus | 5884 | - |
cytoskeleton | recombinant isoenzyme A associates with the cytoskeleton, targeting of IP3kin A to the actin cytoskeleton in transfected HeLa and COS-7 cells | Rattus norvegicus | 5856 | - |
dendrite | recombinant isoenzyme A has an N-terminal 66-amino acid F-actin-binding region that localizes the kinase to dentritic spines, endogenous isoenzyme A is localized to the dentritic spines of pyramidal neurons in primary hippocampal cultures | Rattus norvegicus | 30425 | - |
plasma membrane | recombinant isoenzyme A associates with | Rattus norvegicus | 5886 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 1D-myo-inositol 1,4,5-trisphosphate | Rattus norvegicus | phosphorylation of IP3 in dentritic spines to produce IP4 is important for modulating the compartmentalization of calcium at synapses, control of calcium signals, the rapid, localized synthesis of IP4 may have complex effects on cytosolic calcium and on the molecular mechanisms that control learning and memory | ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
isoenzyme A | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
astrocyte | highest expression of recombinant isoenzyme A in astrocytes of hippocampal cultures transfected with isoenzyme A | Rattus norvegicus | - |
brain | isoform A | Rattus norvegicus | - |
hippocampus | endogenous isoenzyme A is localized to the dentritic spines of pyramidal neurons in primary hippocampal cultures from neonatal rats, highest expression of recombinant isoenzyme A in astrocytes | Rattus norvegicus | - |
neuron | endogenous isoenzyme A is localized to the dentritic spines of pyramidal neurons in primary hippocampal cultures | Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 1D-myo-inositol 1,4,5-trisphosphate | isoform A: N-terminal 66-amino acid F-actin-binding region | Rattus norvegicus | ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate | - |
? | |
ATP + 1D-myo-inositol 1,4,5-trisphosphate | phosphorylation of IP3 in dentritic spines to produce IP4 is important for modulating the compartmentalization of calcium at synapses, control of calcium signals, the rapid, localized synthesis of IP4 may have complex effects on cytosolic calcium and on the molecular mechanisms that control learning and memory | Rattus norvegicus | ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate | - |
? |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Rattus norvegicus |