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Literature summary for 2.7.1.127 extracted from

  • Hague, F.; Matifat, F.; Brule, G.; Collin, T.
    The inositol (1,4,5)-trisphosphate 3-kinase of Xenopus oocyte is activated by CaMKII and involved in the regulation of InsP3-mediated Ca2+ release (1999), FEBS Lett., 449, 71-74.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
EGTA Ca2+/calmodulin-activated enzyme Xenopus laevis
KN-62 calmodulin-dependent protein kinase II inhibitor; prevents the Ca2+/calmodulin-mediated activation Xenopus laevis
KN-93 calmodulin-dependent protein kinase II inhibitor; prevents the Ca2+/calmodulin-mediated activation Xenopus laevis
RS-20 calmodulin antagonist, prevents the Ca2+/calmodulin-mediated activation Xenopus laevis

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Xenopus laevis 5829
-
soluble
-
Xenopus laevis
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ activation is mediated by calmodulin and the calmodulin-dependent protein kinase II Xenopus laevis
Ca2+ activation by Ca2+/calmodulin Xenopus laevis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + 1D-myo-inositol 1,4,5-trisphosphate Xenopus laevis involvement of a calmodulin-dependent protein kinase II-mediated phosphorylation in enzyme regulation, enzyme decreases the Ins(1,4,5)P3 concentration, this second messenger binds to the InsP3 receptor to release Ca2+ from intracellular stores, the activation of enzyme may be involved in the Ca2+-dependent down regulation of the InsP3-mediated Ca2+ release, enzyme may play a key role in regulating signals arising from the phospholipase C-related transduction system ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate Xenopus laevis involved in inositol polyphosphate metabolism ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
?

Organism

Organism UniProt Comment Textmining
Xenopus laevis
-
adult
-

Source Tissue

Source Tissue Comment Organism Textmining
oocyte
-
Xenopus laevis
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
Xenopus laevis

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 1D-myo-inositol 1,4,5-trisphosphate
-
Xenopus laevis ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate involvement of a calmodulin-dependent protein kinase II-mediated phosphorylation in enzyme regulation, enzyme decreases the Ins(1,4,5)P3 concentration, this second messenger binds to the InsP3 receptor to release Ca2+ from intracellular stores, the activation of enzyme may be involved in the Ca2+-dependent down regulation of the InsP3-mediated Ca2+ release, enzyme may play a key role in regulating signals arising from the phospholipase C-related transduction system Xenopus laevis ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate involved in inositol polyphosphate metabolism Xenopus laevis ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Xenopus laevis

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
assay at Xenopus laevis

Cofactor

Cofactor Comment Organism Structure
ATP
-
Xenopus laevis
Calmodulin activation by Ca2+/calmodulin Xenopus laevis
Calmodulin mediates activation by Ca2+ Xenopus laevis