Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | isoenzyme C is regulated by Ca2+ to a lesser extend than isoenzymes A and B | Homo sapiens | |
Ca2+ | activation by Ca2+/calmodulin | Mammalia | |
Ca2+ | activation by Ca2+/calmodulin | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 1D-myo-inositol 1,4,5-trisphosphate | Homo sapiens | - |
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate | - |
? | |
ATP + 1D-myo-inositol 1,4,5-trisphosphate | Mammalia | role in rapidly metabolizing the pool of Ins(1,4,5)P3 that is generated when phospholipase C-coupled receptors are activated, the product Ins(1,3,4,5)P4 can protect Ins(1,4,5)P3 against hydrolysis and therefore increase its effectiveness, detailed consequences of Ins(1,3,4,5)P4 generation in the cell, all 3 isoenzymes are regulated by calmodulin, 2 isoenzymes are regulated by a Ca2+/calmodulin-dependent protein kinase II | ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
3 isoenzymes: A, B and C | - |
Mammalia | - |
at least 3 isoforms: A, B and C | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
additional information | isoenzyme C is not found in brain | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 1D-myo-inositol 1,4,5-trisphosphate | - |
Mammalia | ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate | - |
? | |
ATP + 1D-myo-inositol 1,4,5-trisphosphate | - |
Homo sapiens | ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate | - |
? | |
ATP + 1D-myo-inositol 1,4,5-trisphosphate | role in rapidly metabolizing the pool of Ins(1,4,5)P3 that is generated when phospholipase C-coupled receptors are activated, the product Ins(1,3,4,5)P4 can protect Ins(1,4,5)P3 against hydrolysis and therefore increase its effectiveness, detailed consequences of Ins(1,3,4,5)P4 generation in the cell, all 3 isoenzymes are regulated by calmodulin, 2 isoenzymes are regulated by a Ca2+/calmodulin-dependent protein kinase II | Mammalia | ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate | - |
? |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Mammalia | |
ATP | - |
Homo sapiens | |
Calmodulin | activation by Ca2+/calmodulin | Mammalia | |
Calmodulin | activation by Ca2+/calmodulin | Homo sapiens |