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Literature summary for 2.7.1.127 extracted from

  • Carrasco, M.A.; Figueroa, S.
    Inositol 1,4,5-trisphosphate 3-kinase activity in frog skeletal muscle (1995), Comp. Biochem. Physiol. B, 110, 747-753.
    View publication on PubMed
Search for more literature for 2.7.1.127

Inhibitors

Inhibitors Comment Organism Structure
2,3-diphosphoglycerate
-
 Calyptocephallela gayi
CdCl2
-
 Calyptocephallela gayi
vanadate
-
 Calyptocephallela gayi

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0016
-
 1D-myo-inositol 1,4,5-trisphosphate 25°C Calyptocephallela gayi

Localization

Localization Comment Organism GeneOntology No. Textmining
soluble predominantly Calyptocephallela gayi
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ at physiological concentrations Calyptocephallela gayi
Ca2+ activation by Ca2+/calmodulin Calyptocephallela gayi

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + 1D-myo-inositol 1,4,5-trisphosphate Calyptocephallela gayi important alternative route for inositol 1,4,5-trisphosphate metabolism in skeletal muscle ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Calyptocephallela gayi
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
skeletal muscle
-
 Calyptocephallela gayi
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
 Calyptocephallela gayi

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 1D-myo-inositol 1,4,5-trisphosphate
-
 Calyptocephallela gayi ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
 ?
ATP + 1D-myo-inositol 1,4,5-trisphosphate important alternative route for inositol 1,4,5-trisphosphate metabolism in skeletal muscle Calyptocephallela gayi ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
 around Calyptocephallela gayi

pH Range

pH Minimum pH Maximum Comment Organism
6 8 steep increase in activity on raising pH from pH 6 to an optimum around pH 8 Calyptocephallela gayi

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Calyptocephallela gayi
Calmodulin activation by Ca2+/calmodulin Calyptocephallela gayi