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Literature summary for 2.7.1.127 extracted from

  • Hansen, C.A.; Mah, S.; Williamson, J.R.
    Formation and metabolism of inositol 1,3,4,5-tetrakisphosphate in liver (1986), J. Biol. Chem., 261, 8100-8103.
    View publication on PubMed
Search for more literature for 2.7.1.127

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Rattus norvegicus 5829
-
soluble
-
 Rattus norvegicus
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + 1D-myo-inositol 1,4,5-trisphosphate Rattus norvegicus inositol 1,4,5-trisphosphate and inositol 1,3,4,5-tetrakisphosphate have separate second messenger roles, perhaps both relating to Ca2+-signaling events ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
 ?
ATP + 1D-myo-inositol 1,4,5-trisphosphate Rattus norvegicus involved in inositol polyphosphate metabolism ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
 male sprague-dawley rats
-

Purification (Commentary)

Purification (Comment) Organism
partial Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
brain cortex Rattus norvegicus
-
hepatocyte vasopressin-stimulated cells Rattus norvegicus
-
liver
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.0008
-
 liver Rattus norvegicus
0.002
-
 brain cortex Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 1D-myo-inositol 1,4,5-trisphosphate enzyme is specific for phosphorylating the position 3 of the myo-inositol ring and requires vicinal phosphates in the 4 and 5 positions Rattus norvegicus ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
 ?
ATP + 1D-myo-inositol 1,4,5-trisphosphate inositol 1,4,5-trisphosphate and inositol 1,3,4,5-tetrakisphosphate have separate second messenger roles, perhaps both relating to Ca2+-signaling events Rattus norvegicus ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
 ?
ATP + 1D-myo-inositol 1,4,5-trisphosphate involved in inositol polyphosphate metabolism Rattus norvegicus ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
 ?

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Rattus norvegicus