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Literature summary for 2.7.1.12 extracted from

  • Corkins, M.E.; Wilson, S.; Cocuron, J.C.; Alonso, A.P.; Bird, A.J.
    The gluconate shunt is an alternative route for directing glucose into the pentose phosphate pathway in fission yeast (2017), J. Biol. Chem., 292, 13823-13832 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Schizosaccharomyces pombe

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + D-gluconate Schizosaccharomyces pombe 6-phosphogluconate dehydrogenase (Gcd1) and gluconate kinase (Idn1) act together to shunt glucose into the pentose phosphate pathway, creating an alternative route for directing glucose into the pentose phosphate pathway that bypasses hexokinase and the rate-limiting enzyme glucose-6-phosphate dehydrogenase ADP + 6-phospho-D-gluconate
-
?
ATP + D-gluconate Schizosaccharomyces pombe ATCC 24843 6-phosphogluconate dehydrogenase (Gcd1) and gluconate kinase (Idn1) act together to shunt glucose into the pentose phosphate pathway, creating an alternative route for directing glucose into the pentose phosphate pathway that bypasses hexokinase and the rate-limiting enzyme glucose-6-phosphate dehydrogenase ADP + 6-phospho-D-gluconate
-
?

Organism

Organism UniProt Comment Textmining
Schizosaccharomyces pombe Q10242 the strain is lacking the zinc-responsive transcriptional repressor Loz1 with the goal of identifying metabolic pathways that are altered by cellular zinc status
-
Schizosaccharomyces pombe ATCC 24843 Q10242 the strain is lacking the zinc-responsive transcriptional repressor Loz1 with the goal of identifying metabolic pathways that are altered by cellular zinc status
-

Purification (Commentary)

Purification (Comment) Organism
-
Schizosaccharomyces pombe

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + D-gluconate
-
Schizosaccharomyces pombe ADP + 6-phospho-D-gluconate
-
?
ATP + D-gluconate 6-phosphogluconate dehydrogenase (Gcd1) and gluconate kinase (Idn1) act together to shunt glucose into the pentose phosphate pathway, creating an alternative route for directing glucose into the pentose phosphate pathway that bypasses hexokinase and the rate-limiting enzyme glucose-6-phosphate dehydrogenase Schizosaccharomyces pombe ADP + 6-phospho-D-gluconate
-
?
ATP + D-gluconate
-
Schizosaccharomyces pombe ATCC 24843 ADP + 6-phospho-D-gluconate
-
?
ATP + D-gluconate 6-phosphogluconate dehydrogenase (Gcd1) and gluconate kinase (Idn1) act together to shunt glucose into the pentose phosphate pathway, creating an alternative route for directing glucose into the pentose phosphate pathway that bypasses hexokinase and the rate-limiting enzyme glucose-6-phosphate dehydrogenase Schizosaccharomyces pombe ATCC 24843 ADP + 6-phospho-D-gluconate
-
?

Synonyms

Synonyms Comment Organism
Idn1 gluconate kinase
-
Schizosaccharomyces pombe

General Information

General Information Comment Organism
metabolism 6-phosphogluconate dehydrogenase (Gcd1) and gluconate kinase (Idn1) act together to shunt glucose into the pentose phosphate pathway, creating an alternative route for directing glucose into the pentose phosphate pathway that bypasses hexokinase and the rate-limiting enzyme glucose-6-phosphate dehydrogenase Schizosaccharomyces pombe