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show all sequences of 2.7.1.118

Adenosine diphosphate: thymidine 5-phosphotransferase, a new enzyme activity, associated with the Herpes simplex virus-induced deoxypyrimidine kinase

Falke, D.; Labenz, J.; Brauer, D.; Müller, W.E.G.; Biochim. Biophys. Acta 708, 99-103 (1982)

Data extracted from this reference:

Inhibitors
Inhibitors
Commentary
Organism
Structure
EDTA
-
Herpes simplex virus
N-ethylmaleimide
-
Herpes simplex virus
p-chloromercuribenzoate
-
Herpes simplex virus
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.0005
-
thymidine
Herpes simplex virus type 2
Herpes simplex virus
0.0008
-
thymidine
Herpes simplex virus type 1
Herpes simplex virus
0.012
-
ADP
Herpes simplex virus type 1
Herpes simplex virus
0.019
-
ADP
Herpes simplex virus type 2
Herpes simplex virus
Metals/Ions
Metals/Ions
Commentary
Organism
Structure
Mg2+
10% residual activity in absence of Mg2+
Herpes simplex virus
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ADP + thymidine
Herpes simplex virus
-
AMP + dTMP
-
Herpes simplex virus
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Herpes simplex virus
-
type 1 or type 2, induced in mouse fibroblasts
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
Specific Activity [micromol/min/mg]
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
0.0048
-
-
Herpes simplex virus
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ADP + thymidine
-
640664
Herpes simplex virus
AMP + dTMP
-
640664
Herpes simplex virus
?
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
6.5
7.5
Herpes simplex virus type 1
Herpes simplex virus
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
EDTA
-
Herpes simplex virus
N-ethylmaleimide
-
Herpes simplex virus
p-chloromercuribenzoate
-
Herpes simplex virus
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.0005
-
thymidine
Herpes simplex virus type 2
Herpes simplex virus
0.0008
-
thymidine
Herpes simplex virus type 1
Herpes simplex virus
0.012
-
ADP
Herpes simplex virus type 1
Herpes simplex virus
0.019
-
ADP
Herpes simplex virus type 2
Herpes simplex virus
Metals/Ions (protein specific)
Metals/Ions
Commentary
Organism
Structure
Mg2+
10% residual activity in absence of Mg2+
Herpes simplex virus
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ADP + thymidine
Herpes simplex virus
-
AMP + dTMP
-
Herpes simplex virus
?
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
Specific Activity [micromol/min/mg] (protein specific)
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
0.0048
-
-
Herpes simplex virus
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ADP + thymidine
-
640664
Herpes simplex virus
AMP + dTMP
-
640664
Herpes simplex virus
?
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
6.5
7.5
Herpes simplex virus type 1
Herpes simplex virus
Other publictions for EC 2.7.1.118
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
640571
Labenz
Inhibition of the Herpes simpl ...
Herpes simplex virus
Arch. Virol.
81
205-212
1984
-
-
-
-
-
-
2
-
-
-
-
1
-
2
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
1
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
640664
Falke
Adenosine diphosphate: thymidi ...
Herpes simplex virus
Biochim. Biophys. Acta
708
99-103
1982
-
-
-
-
-
-
3
4
-
1
-
1
-
2
-
-
-
-
-
1
1
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
4
-
1
-
1
-
-
-
-
-
1
1
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
640569
Falke
Adenylic acid: deoxythymidine ...
Herpes simplex virus
J. Gen. Virol.
53
247-255
1981
-
-
-
-
-
-
-
-
-
-
1
1
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-