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Literature summary for 2.7.1.11 extracted from

  • Ismail, R.; Ul Hussain, M.
    The up regulation of phosphofructokinase1 (PFK1) protein during chemically induced hypoxia is mediated by the hypoxia-responsive internal ribosome entry site (IRES) element, present in its untranslated region (2017), Biochimie, 139, 38-45 .
    View publication on PubMed
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + D-fructose 6-phosphate Rattus norvegicus
-
 ADP + D-fructose 1,6-bisphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus P47858
-
-

Source Tissue

Source Tissue Comment Organism Textmining
C6 glioma cell
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + D-fructose 6-phosphate
-
 Rattus norvegicus ADP + D-fructose 1,6-bisphosphate
-
 ?

Synonyms

Synonyms Comment Organism
PFK1
-
 Rattus norvegicus
phosphofructokinase 1
-
 Rattus norvegicus

Expression

Organism Comment Expression
Rattus norvegicus after 48 h of the chemically induced hypoxia induction of the C6 glioma cells, the PFK1 protein depicts strong up regulation, with no appreciable change in its mRNA levels. The presence of a weak internal ribosome entry site (IRES) element in the 5'UTR of the PFK1 mRNA. The weak IRES element of the PFK1 is strongly up regulated after 48 h of the chemically induced hypoxia, indicative of a possible mechanism responsible for the induction of the PFK1 protein up

General Information

General Information Comment Organism
physiological function phosphofructokinase1 (PFK1) is the major regulatory enzyme of the glycolytic pathway Rattus norvegicus