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Literature summary for 2.7.1.11 extracted from

  • Jenkins, C.M.; Yang, J.; Sims, H.F.; Gross, R.W.
    Reversible high affinity inhibition of phosphofructokinase-1 by acyl-CoA: a mechanism integrating glycolytic flux with lipid metabolism (2011), J. Biol. Chem., 286, 11937-11950.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
Arachidonoyl-CoA
-
Oryctolagus cuniculus
linoleoyl-CoA
-
Oryctolagus cuniculus
additional information acetyl-CoA, malonyl-CoA, palmitoylcarnitine, and palmitic acid in the presence of CoASH are without effect on enzyme activity Oryctolagus cuniculus
oleoyl-CoA
-
Oryctolagus cuniculus
palmitoyl-CoA low micromolar inhibitor, MgAMP and MgADP but not MgATP protect the enzyme against inhibition by palmitoyl-CoA. Acyl-protein thioesterase-1 reverses palmitoyl-CoA-mediated enzyme inhibition Oryctolagus cuniculus
palmitoylcarnitine-CoA
-
Oryctolagus cuniculus
S-hexadecyl-CoA
-
Oryctolagus cuniculus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Oryctolagus cuniculus 5829
-

Organism

Organism UniProt Comment Textmining
Oryctolagus cuniculus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
ammonium sulfate precipitation DEAE-Sephacel gel filtration and Bio-Gel filtration Oryctolagus cuniculus

Source Tissue

Source Tissue Comment Organism Textmining
muscle
-
Oryctolagus cuniculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + D-fructose 6-phosphate
-
Oryctolagus cuniculus ADP + D-fructose 1,6-bisphosphate
-
?

Synonyms

Synonyms Comment Organism
6-phosphofructo 1-kinase
-
Oryctolagus cuniculus
PFK-1
-
Oryctolagus cuniculus
phosphofructokinase-1
-
Oryctolagus cuniculus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0015
-
in 50 mM imidazole, pH 8.0, containing 50 mM KCl and 2 mM MgCl2, at 22°C Oryctolagus cuniculus palmitoyl-CoA

General Information

General Information Comment Organism
physiological function the enzyme catalyzes the first committed and rate-determining step of glycolysis and thus represents an essential metabolic control point or node for carbohydrate utilization Oryctolagus cuniculus