Activating Compound | Comment | Organism | Structure |
---|---|---|---|
cAMP | 0.1 mM, approx. 5fold activation | Oryctolagus cuniculus | |
D-fructose 2,6-bisphosphate | half-maximal activation at 0.0003 mM | Oryctolagus cuniculus |
Protein Variants | Comment | Organism |
---|---|---|
R481D | no alteration in nucleotide binding to inhibitory site, 50% inhibition at 0.4-0.7 mM ATP, 10% of wild-type PFK activation with 0.1 mM fructose 2,6-bisphosphate | Oryctolagus cuniculus |
R481L | no alteration in nucleotide binding to inhibitory site, 50% inhibition at 0.4-0.7 mM ATP | Oryctolagus cuniculus |
R48L | similar specific activity as wild-type, less sensitive to ATP inhibition, not inhibited by citrate and 3-phosphoglycerate | Oryctolagus cuniculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
3-phosphoglycerate | 1.5-2.0 mM, 50% inhibition | Oryctolagus cuniculus | |
ATP | 0.4 mM, 50% inhibition of PFK C | Oryctolagus cuniculus | |
citrate | 50% inhibition below 0.25 mM | Oryctolagus cuniculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Oryctolagus cuniculus | - |
- |
- |