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Literature summary for 2.7.1.11 extracted from

  • Sanchez-Martinez, C.; Aragon, J.J.
    Analysis of phosphofructokinase subunits and isozymes in ascites tumor cells and its original tissue, murine mammary gland (1997), FEBS Lett., 409, 86-90.
    View publication on PubMed
Search for more literature for 2.7.1.11

Activating Compound

Activating Compound Comment Organism Structure
D-fructose 2,6-bisphosphate
-
 Rattus norvegicus
D-fructose 2,6-bisphosphate strong stimulation of mammary gland PFK, Kact: 0.00005 mM Mus musculus
additional information ascites tumor PFK is not activated by fructose-1,6-bisphosphate Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
phosphoenolpyruvate inhibition of mammary gland PFK Mus musculus
phosphoenolpyruvate
-
 Rattus norvegicus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
78700
-
 x * 78700, L-type PFK, immunoblot Mus musculus
86200
-
 x * 86200, M-type PFK, immunoblot Mus musculus
87500
-
 x * 87500, c-type PFK, immunoblot Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
Ehrlich ascites carcinoma cell L- and C-type PFK isoenzymes, to a lesser amount M-type PFK Mus musculus
-
mammary gland
-
 Mus musculus
-
mammary gland
-
 Rattus norvegicus
-

Subunits

Subunits Comment Organism
? x * 78700, L-type PFK, immunoblot Mus musculus
? x * 86200, M-type PFK, immunoblot Mus musculus
? x * 87500, c-type PFK, immunoblot Mus musculus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.83
-
 phosphoenolpyruvate pH 7.2, 25°C, mammary gland and ascites tumor PFK Mus musculus