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Literature summary for 2.7.1.108 extracted from
- Arabidopsis DOK1 encodes a functional dolichol kinase involved in reproduction (2015), Plant J., 81, 292-303.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| gene At3g45040 or AtDOK1, DNA and amino acid sequence determination and analysis, a cytidylyltransferase motif-containing gene, phylogenetic tree. The gene complements defects in the growth and N-linked glycosylation of the Saccharomyces cerevisiae sec59 mutant, deficient in dolichol kinase Sec59p | Arabidopsis thaliana |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | construction of two independent lines of T-DNA-tagged AtDOK1 mutants, designated dok1-1 (CS822420; SAIL_529_E06) and dok1-2 (CS856101; WiscDsLox443D6), with T-DNA insertions in exons 8 and 13, respectively. Mutant dok1-1/+ and wild-type seed morphologies show no significant differences, and dok1-1/+ and the wild type did not differ in seed germination rates | Arabidopsis thaliana |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| CTP + dolichol | Arabidopsis thaliana | - |
CDP + dolichyl phosphate | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Arabidopsis thaliana | F4J4C8 | gene At3g45040 or DOK1 | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| anther | DOK1 is highly expressed in tapetum cells and microspores during early anther development | Arabidopsis thaliana | - |
| microspore | - |
Arabidopsis thaliana | - |
| additional information | gene AtDOK1 is expressed in specific cell types involved in meristematic activities, analysis of tissue-specific expression of DOK1 by histochemical GUS staining, overview | Arabidopsis thaliana | - |
| plant ovule | high expression level | Arabidopsis thaliana | - |
| root | root tip of germinating seedlings, and in the founder cells where lateral root growth is initiated | Arabidopsis thaliana | - |
| seedling | root tip of germinating seedlings | Arabidopsis thaliana | - |
| shoot apex | - |
Arabidopsis thaliana | - |
| silique | - |
Arabidopsis thaliana | - |
| tapetum | - |
Arabidopsis thaliana | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| CTP + dolichol | - |
Arabidopsis thaliana | CDP + dolichyl phosphate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| DOK1 | - |
Arabidopsis thaliana |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| CTP | - |
Arabidopsis thaliana | |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | the heterozygous T-DNA-tagged AtDOK1 mutant, dok1-1 and dok1-2, plants show developmental defects in male and female gametophytes, including an aberrant pollen structure, low pollen viability, and short siliques. Additionally, the mutations has incomplete penetrance. Mutation of dok-1 may affect development of siliques but not seed maturation or germination in Arabidopsis thaliana. Male gametophytic defect in dok1 heterozygous plants, overview | Arabidopsis thaliana |
| physiological function | the enzyme is required for reproductive processes in Arabidopsis thaliana | Arabidopsis thaliana |
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