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Literature summary for 2.7.1.107 extracted from

  • Merida, I.; Arranz-Nicolas, J.; Rodriguez-Rodriguez, C.; Avila-Flores, A.
    Diacylglycerol kinase control of protein kinase C (2019), Biochem. J., 476, 1205-1219 .
    View publication on PubMed
Search for more literature for 2.7.1.107

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
 Homo sapiens 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + 1,2-diacyl-sn-glycerol Homo sapiens
-
 ADP + 1,2-diacyl-sn-glycerol 3-phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q13574
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein isoform DGKzeta is phosphorylated by protein kinase Calpha Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
immune system
-
 Homo sapiens
-
nervous system
-
 Homo sapiens
-
T-lymphocyte
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 1,2-diacyl-sn-glycerol
-
 Homo sapiens ADP + 1,2-diacyl-sn-glycerol 3-phosphate
-
 ?
additional information isoform DGKzeta physically and functionally interacts with protein kinase Calpha. Diacylglycerol kinase control of protein kinase C facilitates cell-cell communication Homo sapiens ?
-
-

Synonyms

Synonyms Comment Organism
DGKzeta isoform Homo sapiens

General Information

General Information Comment Organism
physiological function isoform DGKzeta modulates protein kinase C-dependent regulation of synapse plasticity. Isoform DGKzeta interaction with post-synaptic density 95/Discs-large/zona occludens-1-containing scaffolds restricts spatial activation of protein kinase Calpha. Isoform DGKzeta is a negative regulator of T-cell functions and a modulator of innate immunity Homo sapiens