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Literature summary for 2.7.1.107 extracted from
- Expression, purification, and characterization of human diacylglycerol kinase zeta (2019), ACS Omega, 4, 5540-5546 .
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| phosphatidylserine | - |
Homo sapiens |  |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| using a baculovirus-Sf9 insect cell expression system | Homo sapiens |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.05 | - |
ATP | pH and temperature not specified in the publication | Homo sapiens | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 120000 | - |
gel filtration | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + 1,2-diacyl-sn-glycerol | Homo sapiens | - |
ADP + 1,2-diacyl-sn-glycerol 3-phosphate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | Q13574 | - |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| Ni-NTA agarose column chromatography and Superdex S200 gel filtration | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + 1,2-diacyl-sn-glycerol | - |
Homo sapiens | ADP + 1,2-diacyl-sn-glycerol 3-phosphate | - |
? | |
| ATP + 1,2-dilauroyl-sn-glycerol | high activity | Homo sapiens | ADP + 1,2-dilauroyl-sn-glycerol 3-phosphate | - |
? | |
| ATP + 1,2-dioleoyl-sn-glycerol | high activity | Homo sapiens | ADP + 1,2-dioleoyl-sn-glycerol 3-phosphate | - |
? | |
| ATP + 1,2-dipalmitoyl-sn-glycerol | highest activity | Homo sapiens | ADP + 1,2-dipalmitoyl-sn-glycerol 3-phosphate | - |
? | |
| ATP + 1,2-distearoyl-sn-glycerol | high activity | Homo sapiens | ADP + 1,2-distearoyl-sn-glycerol 3-phosphate | - |
? | |
| ATP + 1-palmitoyl-2-oleolyl-sn-glycerol | high activity | Homo sapiens | ADP + 1-palmitoyl-2-oleolyl-sn-glycerol 3-phosphate | - |
? | |
| ATP + 1-stearoyl-2-docosahexaenoyl-sn-glycerol | high activity | Homo sapiens | ADP + 1-stearoyl-2-docosahexaenoyl-sn-glycerol 3-phosphate | - |
? | |
| ATP + 1-stearoyl-2-eicosatetraenoyl-sn-glycerol | high activity | Homo sapiens | ADP + 1-stearoyl-2-eicosatetraenoyl-sn-glycerol 3-phosphate | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| monomer | 1 * 106000, His6-tagged enzyme, calculated from amino acid sequence | Homo sapiens |
| monomer | 1 * 125000, His6-tagged enzyme, SDS-PAGE | Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| DGKzeta | - |
Homo sapiens |
| diacylglycerol kinase zeta | - |
Homo sapiens |
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