Literature summary for 2.7.1.107 extracted from

Hozumi, Y.; Fukaya, M.; Adachi, N.; Saito, N.; Otani, K.; Kondo, H.; Watanabe, M.; Goto, K.
Diacylglycerol kinase beta accumulates on the perisynaptic site of medium spiny neurons in the striatum (2008), Eur. J. Neurosci., 28, 2409-2422.

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Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytoplasm	localized in the narrow cytoplasmic space between smooth endoplasmic reticulum and plasma membrane	Rattus norvegicus	5737	-
plasma membrane	-	Rattus norvegicus	5886	-
smooth endoplasmic reticulum	-	Rattus norvegicus	5790	-

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
90000	-	isoform DGKbeta, SDS-PAGE	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	P49621	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
hippocampus	moderate labeling in the hippocampus	Rattus norvegicus	-
medium spiny neuron	DGKbeta is expressed in medium spiny neurons constituting the striatonigral and striatopallidal pathways, whereas striatal interneurons are below the detection threshold	Rattus norvegicus	-
neocortex	weak labeling in the neocortex	Rattus norvegicus	-
olfactory bulb	weak labeling in the olfactory bulb	Rattus norvegicus	-
striatum	diacylglycerol kinase beta accumulates on the perisynaptic site of medium spiny neurons in the striatum	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + 1,2-diacylglycerol	-	Rattus norvegicus	ADP + 1,2-diacyl-sn-glycerol 3-phosphate	-	?

Synonyms

Synonyms	Comment	Organism
DGKbeta	-	Rattus norvegicus
diacylglycerol kinase beta	-	Rattus norvegicus

Cofactor

Cofactor	Comment	Organism	Structure
ATP	-	Rattus norvegicus

General Information

General Information	Comment	Organism
physiological function	isoform DGKbeta is provided to perisynaptic sites of medium spiny neurons so that it can effectively produce 1,2-diacyl-sn-glycerol 3-phosphate upon activation of Gq protein-coupled receptors and modulate the cellular state of striatal output neurons	Rattus norvegicus

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Release 2023.1 (January 2023)