Literature summary for 2.7.1.105 extracted from

Wang, J.; Xu, J.; Wang, Q.; Brainard, R.E.; Watson, L.J.; Jones, S.P.; Epstein, P.N.
Reduced cardiac fructose 2,6 bisphosphate increases hypertrophy and decreases glycolysis following aortic constriction (2013), PLoS ONE, 8, e53951.

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + beta-D-fructose 6-phosphate	Mus musculus	-	ADP + beta-D-fructose 2,6-bisphosphate	-	?

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	P70265	gene Pfkfb2	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
heart	heart PFK-2 isozyme	Mus musculus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + beta-D-fructose 6-phosphate	-	Mus musculus	ADP + beta-D-fructose 2,6-bisphosphate	-	?

Synonyms

Synonyms	Comment	Organism
Pfk-2	-	Mus musculus

Cofactor

Cofactor	Comment	Organism	Structure
ATP	-	Mus musculus

General Information

General Information	Comment	Organism
malfunction	Mb transgenic mice have reduced fructose 2,6-bisphosphate levels, due to cardiac expression of a transgene for a mutant, kinase deficient form of the enzyme 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2) which controls the level of fructose 2,6-bisphosphate. Mb hearts are markedly more sensitive to transverse aortic constriction-induced damage showing lower fractional shortening in Mb-TAC mice as well as larger left ventricular end diastolic and end systolic diameters. Cardiac hypertrophy and pulmonary congestion are more severe in Mb-transverse aortic constriction mice, Mb transgene exacerbates transverse aortic constriction-induced increases in cardiac hypertrophy and lung weight, detailed phenotype, overview	Mus musculus
physiological function	fructose 2,6-bisphosphate is a positive regulator of the glycolytic enzyme phosphofructokinase	Mus musculus

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Release 2023.1 (January 2023)