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Literature summary for 2.7.1.105 extracted from

  • Li, H.; Guo, X.; Xu, H.; Woo, S.; Halim, V.; Morgan, C.; Wu, C.
    A role for inducible 6-phosphofructo-2-kinase in the control of neuronal glycolysis (2012), J. Nutr. Biochem., 24, :1153-1158.
    View publication on PubMed
Search for more literature for 2.7.1.105

Organism

Organism UniProt Comment Textmining
Mus musculus Q7TS91
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Source Tissue

Source Tissue Comment Organism Textmining
hypothalamus expressed at high abundance in both hypothalami and clonal hypothalamic neurons. In response to re-feeding, isoform PFKFB3 mRNA levels are increased by 10fold in mouse hypothalami Mus musculus
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neuron expressed at high abundance in both hypothalami and clonal hypothalamic neurons Mus musculus
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Synonyms

Synonyms Comment Organism
inducible 6-phosphofructo-2-kinase
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 Mus musculus
iPFK2
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 Mus musculus
PFKFB3
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 Mus musculus

Expression

Organism Comment Expression
Mus musculus upon re-feeding, isoform PFKFB3 mRNA levels are increased by 10fold in mouse hypothalami up

General Information

General Information Comment Organism
physiological function knockdown of isoform PFKFB3/iPFK2 in N-43/5 neurons causes a decrease in rates of glycolysis, which is accompanied by increased AMP-activated protein kinase phosphorylation, increased agouti-related protein mRNA levels and decreased cocaine-amphetamine-related transcript mRNA levels. Overexpression of PFKFB3/iPFK2 in N-43/5 neurons causes an increase in glycolysis, which is accompanied by decreased AMP-activated protein kinase phosphorylation and decreased agouti-related protein mRNA levels and increased cocaine-amphetamine-related transcript mRNA levels Mus musculus