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Literature summary for 2.7.1.105 extracted from
- Endogenous activation of glucokinase by 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase is glucose dependent (2010), Mol. Endocrinol., 24, 1988-1997.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
- |
Rattus norvegicus |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | engineering of the LKVWT glucokinase-binding motif in the FBPase-2 domain of islet PFK-2/FBPase-2 to HKEWR leads to significantly lower interaction with glucokinase compared with wild-type at 25 mmol/liter glucose | Rattus norvegicus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
bifunctional 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| pancreatic islet | - |
Rattus norvegicus | - |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | enzyme acts as an endogenous glucokinase activator. Binding and activation of glucokinase by bifunctional 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase in beta-cells is promoted by glucose, resulting in an enhancement of insulin secretion at stimulatory glucose concentrations, without affecting basal insulin secretion | Rattus norvegicus |
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