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Literature summary for 2.7.1.105 extracted from

  • Chesney, J.; Mitchell, R.; Benigni, F.; Bacher, M.; Spiegel, L.; Al-Abed, Y.; Han, J.H.; Metz, C.; Bucala, R.
    An inducible gene product for 6-phosphofructo-2-kinase with an AU-rich instability element: role in tumor cell glycolysis and the Warburg effect (1999), Proc. Natl. Acad. Sci. USA, 96, 3047-3052.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
isoform of enzyme that is induced by proinflammatory stimuli and that is distinguished by the presence of multiple copies of the AUUUA instability motif in its 3' untranslated region is identified and the complete cDNA is cloned and sequenced, expression in eigth human tumor cell lines Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + beta-D-fructose 6-phosphate Homo sapiens the inducible enzyme is an important regulator of glycolysis that may be responsible for sustaining the high glycolytic flux of rapidly proliferating leukemia cells ADP + beta-D-fructose 2,6-bisphosphate
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Organism

Organism UniProt Comment Textmining
Faxonius limosus
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crayfish
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Homo sapiens Q16875
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Source Tissue

Source Tissue Comment Organism Textmining
midgut gland Faxonius limosus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + beta-D-fructose 6-phosphate
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Homo sapiens ADP + beta-D-fructose 2,6-bisphosphate
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?
ATP + beta-D-fructose 6-phosphate the inducible enzyme is an important regulator of glycolysis that may be responsible for sustaining the high glycolytic flux of rapidly proliferating leukemia cells Homo sapiens ADP + beta-D-fructose 2,6-bisphosphate
-
?