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Literature summary for 2.7.1.105 extracted from

  • Yuen, M.H.; Wang, X.L.; Mizuguchi, H.; Uyeda, K.; Hasemann, C.A.
    A switch in the kinase domain of rat testis 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (1999), Biochemistry, 38, 12333-12342.
    View publication on PubMed
Search for more literature for 2.7.1.105

Crystallization (Commentary)

Crystallization (Comment) Organism
the crystal structure of H256A to a resolution of 2.4 A by molecular replacement Rattus norvegicus

Protein Variants

Protein Variants Comment Organism
H256A crystal structure Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + beta-D-fructose 6-phosphate Rattus norvegicus enzyme plays an indirect yet key role in the regulation of glucose metabolism ADP + beta-D-fructose 2,6-bisphosphate
-
 ?
ATP + beta-D-fructose 6-phosphate Rattus norvegicus responsible for regulation of fructose 2,6-bisphosphate-concentration ADP + beta-D-fructose 2,6-bisphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus P25114
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-

Reaction

Reaction Comment Organism Reaction ID
ATP + beta-D-fructose 6-phosphate = ADP + beta-D-fructose 2,6-bisphosphate mechanism Rattus norvegicus
a
ATP + beta-D-fructose 6-phosphate = ADP + beta-D-fructose 2,6-bisphosphate bifunctional protein: 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase, reverse reaction catalysed by fructose 2,6-bisphosphatase: 3.1.3.46 Rattus norvegicus
a

Source Tissue

Source Tissue Comment Organism Textmining
testis
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + beta-D-fructose 6-phosphate
-
 Rattus norvegicus ADP + beta-D-fructose 2,6-bisphosphate
-
 r
ATP + beta-D-fructose 6-phosphate enzyme plays an indirect yet key role in the regulation of glucose metabolism Rattus norvegicus ADP + beta-D-fructose 2,6-bisphosphate
-
 ?
ATP + beta-D-fructose 6-phosphate responsible for regulation of fructose 2,6-bisphosphate-concentration Rattus norvegicus ADP + beta-D-fructose 2,6-bisphosphate
-
 ?
additional information also catalyses the degradation of fructose 2,6-bisphosphate (EC 3.1.3.46) Rattus norvegicus ?
-
 ?