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Literature summary for 2.7.1.105 extracted from

  • Rider, M.H.; Hue, L.
    Bifunctionality of muscle and heart 6-phosphofructo-2-kinase: skeletal muscle 6-phosphofructo-2-kinase catalyses fructose 2,6-bisphosphate hydrolysis whereas heart 6-phophofructo-2-kinase contains little fructose-2,6-bisphphophatase (1987), Biochem. Soc. Trans., 15, 379-380.
No PubMed abstract available
Search for more literature for 2.7.1.105

Inhibitors

Inhibitors Comment Organism Structure
citrate
-
 Rattus norvegicus
additional information phosphorylation by cAMP-dependent protein kinase causes inactivation of liver enzyme; phosphorylation by cAMP-dependent protein kinase causes inactivation of liver enzyme, not of heart and skeletal muscle enzyme Rattus norvegicus
phosphoenolpyruvate
-
 Rattus norvegicus

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein phosphorylation by cAMP-dependent protein kinase causes inactivation of liver enzyme, not of heart and skeletal muscle enzyme Rattus norvegicus
phosphoprotein phosphorylation by cAMP-dependent protein kinase causes inactivation of liver enzyme Rattus norvegicus

Reaction

Reaction Comment Organism Reaction ID
ATP + beta-D-fructose 6-phosphate = ADP + beta-D-fructose 2,6-bisphosphate bifunctional protein: 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase, reverse reaction catalysed by fructose 2,6-bisphosphatase: 3.1.3.46 Rattus norvegicus
a

Source Tissue

Source Tissue Comment Organism Textmining
heart
-
 Rattus norvegicus
-
liver
-
 Rattus norvegicus
-
skeletal muscle
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.00031
-
 skeletal muscle Rattus norvegicus
0.00295
-
 heart Rattus norvegicus
0.021
-
 liver Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + beta-D-fructose 6-phosphate
-
 Rattus norvegicus ADP + beta-D-fructose 2,6-bisphosphate
-
 r
additional information also catalyses the degradation of fructose 2,6-bisphosphate (EC 3.1.3.46) Rattus norvegicus ?
-
 ?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.026
-
 citrate liver Rattus norvegicus
0.14
-
 citrate skeletal muscle Rattus norvegicus
0.15
-
 citrate heart Rattus norvegicus