BRENDA - Enzyme Database show
show all sequences of 2.7.1.105

Regulation of fructose-2,6-bisphosphate synthesis and breakdown in heart and skeletal muscle

Rider, M.H.; Biochem. Soc. Trans. 15, 988-991 (1987)

Data extracted from this reference:

Inhibitors
Inhibitors
Commentary
Organism
Structure
citrate
skeletal muscle enzyme is more sensitive than liver enzyme
Columba sp.
citrate
skeletal muscle enzyme is more sensitive than liver enzyme
Rattus norvegicus
citrate
-
Bos taurus
additional information
no inhibition by protein kinase C; phosphorylation by cAMP-dependent protein kinase causes inactivation of liver enzyme; rat liver enzyme is inhibited by phosphorylation by cAMP-dependent protein kinase but not rat kidney, testis and skeletal muscle enzyme and bovine and rat heart enzyme
Bos taurus
additional information
no inhibition by protein kinase C; phosphorylation by cAMP-dependent protein kinase causes inactivation of liver enzyme
Columba sp.
additional information
no inhibition by protein kinase C; phosphorylation by cAMP-dependent protein kinase causes inactivation of liver enzyme; rat liver enzyme is inhibited by phosphorylation by cAMP-dependent protein kinase but not rat kidney, testis and skeletal muscle enzyme and bovine and rat heart enzyme
Rattus norvegicus
phosphoenolpyruvate
-
Bos taurus
phosphoenolpyruvate
-
Rattus norvegicus
sn-glycerol 3-phosphate
heart enzyme is less sensitive than liver
Bos taurus
sn-glycerol 3-phosphate
heart enzyme is less sensitive than liver; liver enzyme
Rattus norvegicus
Metals/Ions
Metals/Ions
Commentary
Organism
Structure
Mg2+
-
Columba sp.
Mg2+
-
Bos taurus
Mg2+
-
Rattus norvegicus
phosphate
-
Bos taurus
phosphate
liver enzyme
Rattus norvegicus
phosphate
-
Columba sp.
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ATP + beta-D-fructose 6-phosphate
Rattus norvegicus
responsible for regulation of fructose 2,6-bisphosphate-concentration
ADP + beta-D-fructose 2,6-bisphosphate
-
Rattus norvegicus
?
ATP + beta-D-fructose 6-phosphate
Bos taurus
responsible for regulation of fructose 2,6-bisphosphate-concentration
ADP + beta-D-fructose 2,6-bisphosphate
-
Bos taurus
?
ATP + beta-D-fructose 6-phosphate
Columba sp.
responsible for regulation of fructose 2,6-bisphosphate-concentration
ADP + beta-D-fructose 2,6-bisphosphate
-
Columba sp.
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Bos taurus
-
-
-
Columba sp.
-
-
-
Rattus norvegicus
-
-
-
Posttranslational Modification
Posttranslational Modification
Commentary
Organism
phosphoprotein
phosphorylation by cAMP-dependent protein kinase causes inactivation of liver enzyme; rat liver enzyme is inhibited by phosphorylation by cAMP-dependent protein kinase but not rat kidney, testis and skeletal muscle enzyme and bovine and rat heart enzyme
Bos taurus
phosphoprotein
phosphorylation by cAMP-dependent protein kinase causes inactivation of liver enzyme; rat liver enzyme is inhibited by phosphorylation by cAMP-dependent protein kinase but not rat kidney, testis and skeletal muscle enzyme and bovine and rat heart enzyme
Rattus norvegicus
phosphoprotein
phosphorylation by cAMP-dependent protein kinase causes inactivation of liver enzyme
Columba sp.
Reaction
Reaction
Commentary
Organism
ATP + beta-D-fructose 6-phosphate = ADP + beta-D-fructose 2,6-bisphosphate
bifunctional protein: 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase, reverse reaction catalysed by fructose 2,6-bisphosphatase: 3.1.3.46
Rattus norvegicus
ATP + beta-D-fructose 6-phosphate = ADP + beta-D-fructose 2,6-bisphosphate
bifunctional protein: 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase, reverse reaction catalysed by fructose 2,6-bisphosphatase: 3.1.3.46
Bos taurus
Source Tissue
Source Tissue
Commentary
Organism
Textmining
heart
-
Rattus norvegicus
-
heart
two isozymic forms
Bos taurus
-
liver
-
Bos taurus
-
liver
-
Rattus norvegicus
-
skeletal muscle
-
Columba sp.
-
skeletal muscle
-
Rattus norvegicus
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ATP + beta-D-fructose 6-phosphate
-
640306
Rattus norvegicus
ADP + beta-D-fructose 2,6-bisphosphate
-
-
-
r
ATP + beta-D-fructose 6-phosphate
-
640306
Bos taurus
ADP + beta-D-fructose 2,6-bisphosphate
-
-
-
r
ATP + beta-D-fructose 6-phosphate
-
640306
Columba sp.
ADP + beta-D-fructose 2,6-bisphosphate
-
-
-
r
ATP + beta-D-fructose 6-phosphate
responsible for regulation of fructose 2,6-bisphosphate-concentration
640306
Rattus norvegicus
ADP + beta-D-fructose 2,6-bisphosphate
-
640306
Rattus norvegicus
?
ATP + beta-D-fructose 6-phosphate
responsible for regulation of fructose 2,6-bisphosphate-concentration
640306
Bos taurus
ADP + beta-D-fructose 2,6-bisphosphate
-
640306
Bos taurus
?
ATP + beta-D-fructose 6-phosphate
responsible for regulation of fructose 2,6-bisphosphate-concentration
640306
Columba sp.
ADP + beta-D-fructose 2,6-bisphosphate
-
640306
Columba sp.
?
additional information
also catalyses the degradation of fructose 2,6-bisphosphate (EC 3.1.3.46)
640306
Rattus norvegicus
?
-
-
-
-
additional information
also catalyses the degradation of fructose 2,6-bisphosphate (EC 3.1.3.46)
640306
Bos taurus
?
-
-
-
-
additional information
also catalyses the degradation of fructose 2,6-bisphosphate (EC 3.1.3.46)
640306
Columba sp.
?
-
-
-
-
additional information
with discrete catalytic sites
640306
Rattus norvegicus
?
-
-
-
-
additional information
with discrete catalytic sites
640306
Bos taurus
?
-
-
-
-
additional information
with discrete catalytic sites
640306
Columba sp.
?
-
-
-
-
Cofactor
Cofactor
Commentary
Organism
Structure
AMP
-
Bos taurus
AMP
-
Columba sp.
AMP
-
Rattus norvegicus
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
AMP
-
Bos taurus
AMP
-
Columba sp.
AMP
-
Rattus norvegicus
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
citrate
skeletal muscle enzyme is more sensitive than liver enzyme
Columba sp.
citrate
skeletal muscle enzyme is more sensitive than liver enzyme
Rattus norvegicus
citrate
-
Bos taurus
additional information
no inhibition by protein kinase C; phosphorylation by cAMP-dependent protein kinase causes inactivation of liver enzyme; rat liver enzyme is inhibited by phosphorylation by cAMP-dependent protein kinase but not rat kidney, testis and skeletal muscle enzyme and bovine and rat heart enzyme
Bos taurus
additional information
no inhibition by protein kinase C; phosphorylation by cAMP-dependent protein kinase causes inactivation of liver enzyme
Columba sp.
additional information
no inhibition by protein kinase C; phosphorylation by cAMP-dependent protein kinase causes inactivation of liver enzyme; rat liver enzyme is inhibited by phosphorylation by cAMP-dependent protein kinase but not rat kidney, testis and skeletal muscle enzyme and bovine and rat heart enzyme
Rattus norvegicus
phosphoenolpyruvate
-
Bos taurus
phosphoenolpyruvate
-
Rattus norvegicus
sn-glycerol 3-phosphate
heart enzyme is less sensitive than liver
Bos taurus
sn-glycerol 3-phosphate
heart enzyme is less sensitive than liver; liver enzyme
Rattus norvegicus
Metals/Ions (protein specific)
Metals/Ions
Commentary
Organism
Structure
Mg2+
-
Columba sp.
Mg2+
-
Bos taurus
Mg2+
-
Rattus norvegicus
phosphate
-
Bos taurus
phosphate
liver enzyme
Rattus norvegicus
phosphate
-
Columba sp.
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ATP + beta-D-fructose 6-phosphate
Rattus norvegicus
responsible for regulation of fructose 2,6-bisphosphate-concentration
ADP + beta-D-fructose 2,6-bisphosphate
-
Rattus norvegicus
?
ATP + beta-D-fructose 6-phosphate
Bos taurus
responsible for regulation of fructose 2,6-bisphosphate-concentration
ADP + beta-D-fructose 2,6-bisphosphate
-
Bos taurus
?
ATP + beta-D-fructose 6-phosphate
Columba sp.
responsible for regulation of fructose 2,6-bisphosphate-concentration
ADP + beta-D-fructose 2,6-bisphosphate
-
Columba sp.
?
Posttranslational Modification (protein specific)
Posttranslational Modification
Commentary
Organism
phosphoprotein
phosphorylation by cAMP-dependent protein kinase causes inactivation of liver enzyme; rat liver enzyme is inhibited by phosphorylation by cAMP-dependent protein kinase but not rat kidney, testis and skeletal muscle enzyme and bovine and rat heart enzyme
Bos taurus
phosphoprotein
phosphorylation by cAMP-dependent protein kinase causes inactivation of liver enzyme; rat liver enzyme is inhibited by phosphorylation by cAMP-dependent protein kinase but not rat kidney, testis and skeletal muscle enzyme and bovine and rat heart enzyme
Rattus norvegicus
phosphoprotein
phosphorylation by cAMP-dependent protein kinase causes inactivation of liver enzyme
Columba sp.
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
heart
-
Rattus norvegicus
-
heart
two isozymic forms
Bos taurus
-
liver
-
Bos taurus
-
liver
-
Rattus norvegicus
-
skeletal muscle
-
Columba sp.
-
skeletal muscle
-
Rattus norvegicus
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ATP + beta-D-fructose 6-phosphate
-
640306
Rattus norvegicus
ADP + beta-D-fructose 2,6-bisphosphate
-
-
-
r
ATP + beta-D-fructose 6-phosphate
-
640306
Bos taurus
ADP + beta-D-fructose 2,6-bisphosphate
-
-
-
r
ATP + beta-D-fructose 6-phosphate
-
640306
Columba sp.
ADP + beta-D-fructose 2,6-bisphosphate
-
-
-
r
ATP + beta-D-fructose 6-phosphate
responsible for regulation of fructose 2,6-bisphosphate-concentration
640306
Rattus norvegicus
ADP + beta-D-fructose 2,6-bisphosphate
-
640306
Rattus norvegicus
?
ATP + beta-D-fructose 6-phosphate
responsible for regulation of fructose 2,6-bisphosphate-concentration
640306
Bos taurus
ADP + beta-D-fructose 2,6-bisphosphate
-
640306
Bos taurus
?
ATP + beta-D-fructose 6-phosphate
responsible for regulation of fructose 2,6-bisphosphate-concentration
640306
Columba sp.
ADP + beta-D-fructose 2,6-bisphosphate
-
640306
Columba sp.
?
additional information
also catalyses the degradation of fructose 2,6-bisphosphate (EC 3.1.3.46)
640306
Rattus norvegicus
?
-
-
-
-
additional information
also catalyses the degradation of fructose 2,6-bisphosphate (EC 3.1.3.46)
640306
Bos taurus
?
-
-
-
-
additional information
also catalyses the degradation of fructose 2,6-bisphosphate (EC 3.1.3.46)
640306
Columba sp.
?
-
-
-
-
additional information
with discrete catalytic sites
640306
Rattus norvegicus
?
-
-
-
-
additional information
with discrete catalytic sites
640306
Bos taurus
?
-
-
-
-
additional information
with discrete catalytic sites
640306
Columba sp.
?
-
-
-
-
Other publictions for EC 2.7.1.105
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
749813
Yalcin
6-phosphofructo-2-kinase/fruc ...
Homo sapiens
Biochem. Biophys. Res. Commun.
484
687-693
2017
-
-
-
-
-
-
-
-
-
-
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1
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1
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1
-
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-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
751761
Ros
6-Phosphofructo-2-kinase/fruc ...
Homo sapiens
Oncogene
36
3287-3299
2017
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
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1
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1
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1
-
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-
-
-
-
-
-
-
-
-
1
1
1
1
-
-
751774
Yan
6-Phosphofructo-2-kinase/fruc ...
Homo sapiens
Oncotarget
8
80909-80922
2017
-
-
-
-
1
-
-
-
2
-
-
-
-
1
-
-
-
-
-
2
-
-
-
-
-
-
-
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1
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2
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-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
752141
Crochet
Crystal structure of heart 6- ...
Bos taurus, Homo sapiens
Proteins
85
117-124
2017
-
-
2
2
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
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2
-
2
-
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-
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-
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-
-
-
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
749587
Lea
Inhibition of growth by combi ...
Homo sapiens
Anticancer Res.
36
1479-1488
2016
-
1
-
-
-
-
2
-
-
-
-
-
-
1
-
-
-
-
-
11
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
11
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
739205
Strohecker
Identification of 6-phosphofru ...
Homo sapiens
Oncogene
34
5662-5676
2015
-
-
-
-
1
-
-
-
-
1
-
1
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
1
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
3
3
-
-
-
751765
Du
miR-26b inhibits proliferatio ...
Homo sapiens
Oncol. Rep.
33
1890-1898
2015
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
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-
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-
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-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
729389
Brooke
Targeting the Warburg Effect i ...
Homo sapiens
Bioorg. Med. Chem.
22
1029-1039
2014
-
-
1
-
-
-
28
-
-
1
-
1
-
1
-
-
1
-
-
-
-
-
1
-
1
-
-
-
1
-
-
1
-
-
24
-
-
1
1
-
-
-
24
28
-
-
-
1
-
1
-
-
-
1
-
-
-
-
1
-
1
-
-
-
1
-
-
-
-
1
1
-
-
-
730530
Chesney
Fructose-2,6-bisphosphate synt ...
Homo sapiens
Oncotarget
5
6670-6686
2014
-
2
-
-
1
-
-
-
-
1
-
1
-
1
-
-
-
-
-
20
-
-
2
-
-
-
-
-
-
-
-
1
-
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-
-
2
-
1
-
1
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1
-
1
-
-
-
-
-
20
-
-
2
-
-
-
-
-
-
-
-
-
1
2
2
1
-
-
737752
Cullen
Glucagon induces translocation ...
Rattus norvegicus, Rattus norvegicus Wistar
Biochim. Biophys. Acta
1843
1123-1134
2014
-
-
-
-
1
-
1
-
1
1
-
4
-
5
-
1
-
-
-
2
-
-
4
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
1
-
-
1
-
-
1
1
-
4
-
-
1
-
-
2
-
-
4
-
-
-
-
-
-
-
-
-
-
2
2
-
-
-
737974
Klarer
Inhibition of 6-phosphofructo- ...
Homo sapiens
Cancer Metab.
2
0000
2014
-
-
1
-
-
-
1
-
-
-
-
1
-
2
-
-
-
-
-
3
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
1
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
3
-
-
1
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
737997
Yalcin
6-Phosphofructo-2-kinase (PFKF ...
Homo sapiens
Cell Death Dis.
5
e1337
2014
-
-
-
-
1
-
1
-
1
-
-
1
-
2
-
-
-
-
-
6
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
1
-
-
1
-
-
1
-
-
1
-
-
-
-
-
6
-
-
1
-
-
-
-
-
-
-
-
-
-
3
3
-
-
-
729793
Pegoraro
Pfkfb (6-phosphofructo-2-kinas ...
Xenopus laevis
Gene Expr. Patterns
13
203-211
2013
-
-
1
-
-
-
-
-
-
1
-
3
-
3
-
-
-
-
-
2
-
-
3
-
-
-
-
-
-
-
-
1
-
-
-
-
-
3
3
-
-
-
-
-
-
-
-
3
-
3
-
-
-
-
-
6
-
-
3
-
-
-
-
-
-
-
-
-
-
2
6
-
-
-
730008
Novellasdemunt
Akt-dependent activation of th ...
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4
1
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Watanabe
Enzymic and fluorescence studi ...
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1996
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2
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640341
Garcia de Frutos
The muscle isoform of 6-phosph ...
Sparus aurata
Arch. Biochem. Biophys.
321
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1995
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2
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1
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640310
García de Frutos
6-Phosphofructo 2-kinase/fruct ...
Sparus aurata
Arch. Biochem. Biophys.
308
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1994
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5
3
5
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1
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3
1
1
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1
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94952
Pyko
6-Phosphofructo-2-kinase/fruct ...
Pelophylax esculentus
J. Comp. Physiol. B
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89-98
1993
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1
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1
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2
1
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-
1
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640305
Lange
Expression of human liver 6-ph ...
Homo sapiens, Rattus norvegicus
J. Biol. Chem.
268
8078-8084
1993
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2
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2
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8
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1
2
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2
2
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4
2
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8
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3
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1
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2
2
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4
2
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640307
Li
Isolation of a cDNA for chicke ...
Gallus gallus, Rattus norvegicus
Biochem. Biophys. Res. Commun.
190
397-405
1993
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2
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1
9
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8
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1
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2
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4
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9
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2
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4
-
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640292
Martín-Sanz
-
Characterization of 6-phosphof ...
Rattus norvegicus
Biochem. J.
281
457-463
1992
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1
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3
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1
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1
2
-
1
1
-
-
-
-
-
-
-
-
-
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640302
Rider
-
The two forms of bovine heart ...
Bos taurus, Rattus norvegicus
Biochem. J.
285
405-411
1992
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2
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1
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4
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1
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4
1
-
4
4
-
-
-
-
-
-
-
-
-
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-
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640304
Ventura
Bovine brain 6-phosphofructo-2 ...
Bos taurus
J. Biol. Chem.
267
17939-17943
1992
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3
2
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2
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2
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1
1
1
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1
1
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2
1
1
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3
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2
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2
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1
1
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1
1
-
2
1
1
-
-
-
-
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-
-
-
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640312
Vásquez-Illanes
-
Regulation of fructose-2,6-bis ...
Mytilus galloprovincialis
Mar. Biol.
112
277-281
1992
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-
-
-
-
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2
2
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1
2
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1
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1
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1
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1
1
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2
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2
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1
2
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1
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1
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-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
640318
Harmsen
-
Regulation of 6-phosphofructo- ...
Aspergillus niger
Appl. Microbiol. Biotechnol.
37
784-788
1992
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1
5
2
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2
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1
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1
1
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1
1
1
1
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1
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5
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2
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2
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1
1
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1
1
1
1
-
-
-
-
-
-
-
-
-
-
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-
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94949
Sakata
Characterization of two isozym ...
Bos taurus
Biochem. Biophys. Res. Commun.
180
470-474
1991
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-
-
-
-
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1
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1
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1
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1
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2
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1
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1
-
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2
2
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-
-
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-
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640314
Vásquez-Illanes
Phosphorylation-activated 6-ph ...
Mytilus galloprovincialis
FEBS Lett.
295
176-178
1991
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-
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2
1
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1
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1
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2
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2
2
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2
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1
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1
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1
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-
2
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-
-
-
-
2
2
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-
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640299
Sakata
Bovine heart fructose-6-phosph ...
Bos taurus
Proc. Natl. Acad. Sci. USA
87
4951-4955
1990
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1
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1
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1
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1
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2
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1
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1
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1
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2
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640295
Kitamura
Purification and characterizat ...
Rattus norvegicus
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264
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1989
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1
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1
1
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2
1
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2
1
1
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1
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1
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2
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1
3
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1
1
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2
1
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2
1
1
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1
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640309
Rider
Inactivation of liver 6-phosph ...
Gallus gallus
Biochem. J.
262
97-102
1989
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1
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1
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1
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1
1
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-
1
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-
1
-
-
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-
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-
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640313
Bedri
Kinetics of 6-phosphofructo-2- ...
Saccharomyces cerevisiae
Biomed. Biochim. Acta
48
403-411
1989
-
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-
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2
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1
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2
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1
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1
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1
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2
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1
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1
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1
-
1
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-
-
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94928
Francois
Characterization of phosphofru ...
Saccharomyces cerevisiae
Eur. J. Biochem.
171
599-608
1988
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3
1
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4
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1
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1
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1
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1
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2
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3
2
1
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2
1
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1
1
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1
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1
-
1
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640291
Lively
Complete amino acid sequence o ...
Rattus norvegicus
J. Biol. Chem.
263
839-849
1988
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1
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1
1
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1
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2
1
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-
-
-
-
-
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1
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2
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1
1
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1
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2
1
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640303
Kitamura
Purification and characterizat ...
Bos taurus, Rattus norvegicus
J. Biol. Chem.
263
9027-9033
1988
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3
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2
1
2
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2
1
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4
4
2
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1
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
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3
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2
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2
1
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2
1
-
4
4
2
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-
1
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94929
Walker
ATP-dependent activation of a ...
Spinacia oleracea
Arch. Biochem. Biophys.
258
58-64
1987
1
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1
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1
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1
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-
1
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1
2
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1
-
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-
2
2
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-
-
1
-
-
-
-
-
-
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-
-
1
-
1
-
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-
1
-
1
-
1
2
-
1
-
-
-
2
2
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94931
Kretschmer
Fructose-2,6-bisphosphatase an ...
Saccharomyces cerevisiae
Biochem. J.
246
755-759
1987
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1
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-
1
-
1
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-
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-
1
-
-
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-
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1
-
-
1
-
1
-
-
-
-
-
-
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94932
Loiseau
-
Purification and properties of ...
Rattus norvegicus
Biochem. Soc. Trans.
15
384-385
1987
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4
1
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2
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1
1
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-
2
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-
2
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-
-
-
-
-
-
-
-
5
-
-
-
-
-
-
-
-
-
-
4
5
1
-
2
-
1
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-
1
1
-
2
-
-
2
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-
-
-
-
-
-
-
-
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640306
Rider
Regulation of fructose-2,6-bis ...
Bos taurus, Columba sp., Rattus norvegicus
Biochem. Soc. Trans.
15
988-991
1987
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-
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10
-
-
6
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3
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3
-
3
-
2
-
6
-
-
12
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
3
-
-
-
-
10
-
-
-
6
-
3
-
-
3
-
-
6
-
-
12
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
640317
Walker
-
Spinach leaf 6-phosphofructo-2 ...
Spinacia oleracea
FEBS Lett.
213
375-380
1987
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-
-
-
-
-
-
2
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1
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1
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1
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-
1
-
-
1
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
1
-
-
-
-
-
1
-
1
-
-
1
-
-
-
-
-
-
2
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-
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640321
Aragón
Identification of two forms of ...
Saccharomyces cerevisiae
FEBS Lett.
226
121-124
1987
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4
2
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1
1
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2
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1
1
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-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
4
-
2
-
1
1
-
-
-
1
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
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640324
Rider
-
Bifunctionality of muscle and ...
Rattus norvegicus
Biochem. Soc. Trans.
15
379-380
1987
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-
-
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3
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1
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1
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1
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1
-
3
3
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2
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-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
3
3
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-
1
-
-
-
-
1
-
-
3
3
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
94935
El-Maghrabi
Tissue distribution, immunorea ...
Bos taurus, Canis lupus familiaris, Rattus norvegicus
Proc. Natl. Acad. Sci. USA
83
5005-5009
1986
1
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-
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-
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2
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2
2
2
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4
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2
1
-
-
10
-
-
9
3
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-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
2
-
-
-
2
2
2
-
-
2
1
-
10
-
-
9
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
94936
Van Schaftingen
Purification and properties of ...
Columba sp., Gallus gallus
Eur. J. Biochem.
159
359-365
1986
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-
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4
4
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2
4
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3
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2
2
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-
4
1
-
6
2
2
-
-
-
2
2
-
-
4
-
-
-
-
-
-
-
-
-
-
4
4
4
-
2
4
-
-
-
2
2
-
4
1
-
6
2
2
-
-
-
2
2
-
-
-
-
-
-
-
-
640290
Kountz
-
Hepatic 6-phosphofructo-2-kina ...
Rattus norvegicus
Arch. Biochem. Biophys.
251
110-113
1986
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7
1
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2
1
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1
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1
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1
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-
3
1
1
-
-
-
-
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-
-
1
-
-
-
-
-
-
-
-
-
-
7
1
1
-
2
1
-
-
-
-
-
-
1
-
-
3
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
640315
Larondelle
Purification and properties of ...
Helianthus tuberosus, Ricinus communis, Spinacia oleracea
Eur. J. Biochem.
161
351-357
1986
-
-
-
-
-
1
8
1
-
2
5
-
-
6
-
2
1
-
-
3
1
2
3
3
3
-
-
-
1
-
-
-
12
-
-
-
-
-
-
-
-
1
-
8
12
1
-
2
5
-
-
-
2
1
-
3
1
2
3
3
3
-
-
-
1
-
-
-
-
-
-
-
-
-
640288
Laloux
Phosphate dependency of phosph ...
Rattus norvegicus, Saccharomyces cerevisiae, Spinacia oleracea
Eur. J. Biochem.
148
155-159
1985
-
-
-
-
-
-
9
-
-
7
-
-
-
5
-
3
-
-
-
2
-
-
3
-
3
-
1
-
-
-
-
5
-
-
-
-
-
-
5
-
-
-
-
9
-
-
-
7
-
-
-
-
3
-
-
2
-
-
3
-
3
-
1
-
-
-
-
-
-
-
-
-
-
-
640289
Sakakibara
Studies of the structure of fr ...
Rattus norvegicus
Biochemistry
24
6818-6824
1985
-
-
-
-
-
-
-
-
-
-
3
-
-
1
-
-
1
1
-
1
-
-
2
1
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
1
-
1
-
-
2
1
-
-
-
-
-
-
-
1
-
-
-
-
-
-
640297
Pilkis
The sugar phosphate specificit ...
Rattus norvegicus
J. Biol. Chem.
260
7551-7556
1985
-
-
-
-
-
-
1
4
-
-
-
-
-
2
-
-
-
-
-
1
-
-
7
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
1
4
-
-
-
-
-
-
-
-
-
1
-
-
7
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
640298
Rider
Comparison of purified bovine ...
Bos taurus, Rattus norvegicus
Biochem. J.
231
193-196
1985
-
-
-
-
-
-
6
5
-
2
4
2
-
4
-
2
2
2
-
8
2
-
6
2
2
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
6
-
5
-
2
4
2
-
-
2
2
-
8
2
-
6
2
2
-
-
-
2
-
-
-
-
-
-
-
-
-
640300
Kountz
Isolation and characterization ...
Bos taurus, Rattus norvegicus
Arch. Biochem. Biophys.
238
531-543
1985
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-
-
-
-
-
2
1
-
4
4
-
-
4
-
-
1
2
-
3
2
-
5
2
-
-
-
-
3
1
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
1
-
4
4
-
-
-
-
1
-
3
2
-
5
2
-
-
-
-
3
1
-
-
-
-
-
-
-
-
640323
Guixé
Effect of ATP on phosphofructo ...
Escherichia coli
J. Biol. Chem.
260
11001-11005
1985
-
-
-
-
-
-
3
10
-
1
-
-
-
2
-
1
-
-
-
-
-
-
5
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
3
3
10
-
1
-
-
-
-
1
-
-
-
-
-
5
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
640284
Kretschmer
Inhibition of rat liver phosph ...
Rattus norvegicus
Biochem. Biophys. Res. Commun.
124
793-796
1984
-
-
-
-
-
-
2
2
-
-
-
-
-
2
-
-
-
-
-
2
-
-
1
-
1
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
2
2
2
-
-
-
-
-
-
-
-
-
2
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
640285
Sakakibara
Differences in kinetic propert ...
Rattus norvegicus
J. Biol. Chem.
259
41-46
1984
-
-
-
-
-
1
1
1
-
-
-
-
-
1
-
1
1
1
-
1
1
1
2
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
1
-
-
-
-
-
-
1
1
-
1
1
1
2
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
640286
Pilkis
Evidence for two catalytic sit ...
Rattus norvegicus
J. Biol. Chem.
259
949-958
1984
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-
-
-
-
-
5
4
-
2
-
-
-
1
-
-
-
1
-
1
-
-
6
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
5
-
4
-
2
-
-
-
-
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-
-
1
-
-
6
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
640287
Kitajima
Kinetic studies of fructose 6- ...
Rattus norvegicus
J. Biol. Chem.
259
6896-6903
1984
-
-
-
-
-
-
2
3
-
1
-
-
-
1
-
-
-
1
-
1
-
-
4
-
1
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
2
1
3
-
1
-
-
-
-
-
-
-
1
-
-
4
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
640320
Yamashoji
-
Yeast 6-phosphpfructo-2-kinase ...
Saccharomyces cerevisiae
FEBS Lett.
172
51-54
1984
-
-
-
-
-
-
-
2
-
2
1
-
-
1
-
-
1
-
-
-
1
1
2
-
1
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
2
1
-
-
-
-
1
-
-
1
1
2
-
1
-
-
-
2
-
-
-
-
-
-
-
-
-
640283
El-Maghrabi
Cyclic AMP-dependent phosphory ...
Rattus norvegicus
Biochem. Biophys. Res. Commun.
106
794-802
1982
-
-
-
-
-
-
1
2
-
-
2
-
-
1
-
1
1
1
-
1
1
-
2
1
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
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-
1
-
2
-
-
2
-
-
-
1
1
-
1
1
-
2
1
-
-
-
-
-
-
-
1
-
-
-
-
-
-
640281
Van Schaftingen
Phosphofructokinase 2: the enz ...
Rattus norvegicus
Biochem. Biophys. Res. Commun.
101
1078-1084
1981
-
-
-
-
-
-
2
2
1
2
-
-
-
1
-
1
1
-
-
2
2
-
2
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
2
-
2
1
2
-
-
-
-
1
1
-
2
2
-
2
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
640282
El-Maghrabi
Partial purification of a rat ...
Rattus norvegicus
Biochem. Biophys. Res. Commun.
101
1071-1077
1981
-
-
-
-
-
-
-
3
1
1
1
-
-
1
-
-
1
-
-
1
1
-
5
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
1
1
1
-
-
-
-
1
-
1
1
-
5
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
640294
Van Schaftingen
Inactivation of phosphofructok ...
Rattus norvegicus
Biochem. Biophys. Res. Commun.
103
362-368
1981
-
-
-
-
-
-
3
1
1
2
-
-
-
1
-
1
-
-
-
1
-
-
1
-
1
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
1
1
2
-
-
-
-
1
-
-
1
-
-
1
-
1
-
-
-
3
-
-
-
-
-
-
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-