Literature summary for 2.7.1.1 extracted from

Aljamal, J.; Badawneh, M.
In vitro inhibition of human erythrocyte hexokinase by various hyperglycemic drugs (2017), J. Biochem. Mol. Toxicol., 31, e21910 .

Search for more literature for 2.7.1.1

Inhibitors

Inhibitors	Comment	Organism	Structure
atorvastatin	-	Homo sapiens
chlorpromazine	-	Homo sapiens
clozapine	-	Homo sapiens
diltiazem	-	Homo sapiens
enalaprilat	-	Homo sapiens
gabapentin	-	Homo sapiens
gatifloxacin	-	Homo sapiens
indomethacin	-	Homo sapiens
Valproic acid	-	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P19367	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Homo sapiens

Source Tissue

Source Tissue	Comment	Organism	Textmining
erythrocyte	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + D-glucose	-	Homo sapiens	ADP + D-glucose 6-phosphate	-	?

Synonyms

Synonyms	Comment	Organism
HK-R	-	Homo sapiens

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.015	-	indomethacin	pH 8.5, 37°C	Homo sapiens
0.015	-	atorvastatin	pH 8.5, 37°C	Homo sapiens

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.005	-	pH 8.5, 37°C	Homo sapiens	indomethacin
0.006	-	pH 8.5, 37°C	Homo sapiens	clozapine
0.008	-	pH 8.5, 37°C	Homo sapiens	gatifloxacin
0.01	-	pH 8.5, 37°C	Homo sapiens	enalaprilat
0.03	-	pH 8.5, 37°C	Homo sapiens	gabapentin
0.033	-	pH 8.5, 37°C	Homo sapiens	diltiazem
0.034	-	pH 8.5, 37°C	Homo sapiens	Valproic acid
0.044	-	pH 8.5, 37°C	Homo sapiens	atorvastatin
0.077	-	pH 8.5, 37°C	Homo sapiens	chlorpromazine

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)