Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-deoxy-D-glucose | competitive, compound also inhibits the parasite growth in vitro at concentrations nontoxic to host cells | Cryptosporidium parvum |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.109 | - |
D-mannose | pH 7.5, temperature not specified in the publication | Cryptosporidium parvum | |
0.183 | - |
D-glucose | pH 7.5, temperature not specified in the publication | Cryptosporidium parvum | |
0.673 | - |
ATP | pH 7.5, temperature not specified in the publication | Cryptosporidium parvum | |
6.49 | - |
D-fructose | pH 7.5, temperature not specified in the publication | Cryptosporidium parvum |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Cryptosporidium parvum | Q5CWT5 | - |
- |
Cryptosporidium parvum Iowa II | Q5CWT5 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
additional information | gene is expressed in all life cycle stages | Cryptosporidium parvum | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + D-fructose | - |
Cryptosporidium parvum | ADP + D-fructose 6-phosphate | 8.6% of the activity with ATP | ? | |
ATP + D-fructose | - |
Cryptosporidium parvum Iowa II | ADP + D-fructose 6-phosphate | 8.6% of the activity with ATP | ? | |
ATP + D-glucose | ATP is the preferred nucleside triphosphate | Cryptosporidium parvum | ADP + D-glucose 6-phosphate | - |
? | |
ATP + D-glucose | ATP is the preferred nucleside triphosphate | Cryptosporidium parvum Iowa II | ADP + D-glucose 6-phosphate | - |
? | |
ATP + D-mannose | - |
Cryptosporidium parvum | ADP + D-mannose 6-phosphate | 52% of the activity with ATP | ? | |
ATP + D-mannose | - |
Cryptosporidium parvum Iowa II | ADP + D-mannose 6-phosphate | 52% of the activity with ATP | ? | |
CTP + D-glucose | - |
Cryptosporidium parvum | CDP + D-glucose 6-phosphate | - |
? | |
CTP + D-glucose | - |
Cryptosporidium parvum Iowa II | CDP + D-glucose 6-phosphate | - |
? | |
additional information | no substrates: D-galactose, sorbose. TTP, UTP, CTP and GTP show 6.5%-17.1% of the activity with ATP | Cryptosporidium parvum | ? | - |
? | |
additional information | no substrates: D-galactose, sorbose. TTP, UTP, CTP and GTP show 6.5%-17.1% of the activity with ATP | Cryptosporidium parvum Iowa II | ? | - |
? |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.02 | - |
D-fructose | pH 7.5, temperature not specified in the publication | Cryptosporidium parvum | |
9.5 | - |
ATP | pH 7.5, temperature not specified in the publication | Cryptosporidium parvum | |
12.1 | - |
D-mannose | pH 7.5, temperature not specified in the publication | Cryptosporidium parvum | |
20.5 | - |
D-glucose | pH 7.5, temperature not specified in the publication | Cryptosporidium parvum |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.34 | - |
2-deoxy-D-glucose | pH 7.5, temperature not specified in the publication | Cryptosporidium parvum |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
5.75 | - |
pH 7.5, temperature not specified in the publication | Cryptosporidium parvum | 2-deoxy-D-glucose |