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Literature summary for 2.7.1.1 extracted from

  • Chen, T.; Yu, J.; Tang, Z.; Xie, Z.; Lin, Z.; Sun, H.; Wan, S.; Li, X.; Huang, Y.; Yu, X.; Xu, J.
    Advanced enzymology, expression profile and immune response of Clonorchis sinensis hexokinase show its application potential for prevention and control of clonorchiasis (2015), PLoS Negl. Trop. Dis., 9, e0003641.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine hexokinase is distributed in the worm extensively as well as in liver tissue and serum from infected rats. High-level specific IgG1 and IgG2a are induced in rats by immunization with recombinant enzyme. The enzymatic activity of hexokinase is suppressed by the antibodies in vitro, and the survival of Clonorchis sinensis is inhibited by the antibodies in vivo and in vitro Clonorchis sinensis

Organism

Organism UniProt Comment Textmining
Clonorchis sinensis
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Source Tissue

Source Tissue Comment Organism Textmining
additional information hexokinase is distributed in the worm extensively as well as in liver tissue and serum from Clonorchis sinensis infected rats Clonorchis sinensis
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + D-fructose
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Clonorchis sinensis ADP + D-fructose 6-phosphate 16.6% of the activity with ATP ?
ATP + D-glucose
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Clonorchis sinensis ADP + D-glucose 6-phosphate
-
?
ATP + D-mannose
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Clonorchis sinensis ADP + D-mannose 6-phosphate 97% of the activity with ATP ?
CTP + D-glucose
-
Clonorchis sinensis CDP + D-glucose 6-phosphate 18% of the activity with ATP ?
GTP + D-glucose
-
Clonorchis sinensis GDP + D-glucose 6-phosphate 14% of the activity with ATP ?
ITP + D-glucose
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Clonorchis sinensis IDP + D-glucose 6-phosphate 35% of the activity with ATP ?
TTP + D-glucose
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Clonorchis sinensis TDP + D-glucose 6-phosphate 21% of the activity with ATP ?
UTP + D-glucose
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Clonorchis sinensis UDP + D-glucose 6-phosphate 13% of the activity with ATP ?