Protein Variants | Comment | Organism |
---|---|---|
F199A | mutation in mTOR signaling motif. While overexpressed wild-type enzyme associates with mTOR and raptor, mutant F199A does not show association above control levels | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | P27881 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
cardiomyocyte | ventricular myocyte | Rattus norvegicus | - |
Synonyms | Comment | Organism |
---|---|---|
hexokinase-II | - |
Rattus norvegicus |
General Information | Comment | Organism |
---|---|---|
physiological function | inhibition of hexokinase-II diminishes, while overexpression of hexokinase-II potentiates autophagy induced by glucose deprivation in cardiomyocyte and noncardiomyocyte cells. Hexokinase-II binds to and inhibits the autophagy suppressor, mTOR complex 1 (TORC1), and this binding is increased by glucose deprivation. Mutating the TOS motif, a scaffold sequence responsible for binding TORC1 substrates, in hexokinase-II blocks its ability to bind to TORC1 and regulate protective autophagy. The transition from glycolysis to autophagy appears to be regulated by a decrease in glucose-6 phosphate | Rattus norvegicus |