Literature summary for 2.7.1.1 extracted from

Lama, J.L.; Bell, R.A.; Storey, K.B.
Hexokinase regulation in the hepatopancreas and foot muscle of the anoxia-tolerant marine mollusc, Littorina littorea (2013), Comp. Biochem. Physiol. B, 166, 109-116.

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Inhibitors

Inhibitors	Comment	Organism	Structure
KCl	-	Littorina littorea
NaCl	-	Littorina littorea
NH4Cl	-	Littorina littorea
Urea	-	Littorina littorea

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.059	-	D-glucose	enzyme from hepatopancreas, 24 h anoxic conditions, pH 7.5, 22°C	Littorina littorea
0.091	-	D-glucose	enzyme from hepatopancreas, pH 7.5, 22°C	Littorina littorea
0.14	-	ATP	enzyme from hepatopancreas, 24 h anoxic conditions, pH 7.5, 22°C	Littorina littorea
0.15	-	D-glucose	enzyme from foot muscle, 24 h anoxic conditions, pH 7.5, 22°C	Littorina littorea
0.15	-	D-glucose	enzyme from foot muscle, pH 7.5, 22°C	Littorina littorea
0.16	-	ATP	enzyme from hepatopancreas, pH 7.5, 22°C	Littorina littorea
0.24	-	ATP	enzyme from foot muscle, pH 7.5, 22°C	Littorina littorea
0.55	-	ATP	enzyme from foot muscle, 24 h anoxic conditions, pH 7.5, 22°C	Littorina littorea

Organism

Organism	UniProt	Comment	Textmining
Littorina littorea	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
foot muscle	during anoxia, an increase in Km for ATP and a decrease in Vmax for anoxic snail hexokinase are consistent with a less active enzyme	Littorina littorea	-
hepatopancreas	during anoxia, a reduction in the Km for glucose for hexokinase from the anoxic animal suggests a more active enzyme form	Littorina littorea	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + D-glucose	-	Littorina littorea	ADP + D-glucose 6-phosphate	-	?

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
190	-	enzyme from foot muscle, 24 h anoxic conditions, pH 7.5, 22°C	Littorina littorea	NH4Cl
210	-	enzyme from foot muscle, pH 7.5, 22°C	Littorina littorea	NH4Cl
230	-	enzyme from hepatopancreas, 24 h anoxic conditions, pH 7.5, 22°C	Littorina littorea	NH4Cl
230	-	enzyme from hepatopancreas, pH 7.5, 22°C	Littorina littorea	NH4Cl
240	-	enzyme from hepatopancreas, pH 7.5, 22°C	Littorina littorea	NaCl
260	-	enzyme from hepatopancreas, 24 h anoxic conditions, pH 7.5, 22°C	Littorina littorea	KCl
260	-	enzyme from hepatopancreas, pH 7.5, 22°C	Littorina littorea	KCl
280	-	enzyme from foot muscle, 24 h anoxic conditions, pH 7.5, 22°C	Littorina littorea	KCl
280	-	enzyme from foot muscle, pH 7.5, 22°C	Littorina littorea	NaCl
280	-	enzyme from foot muscle, pH 7.5, 22°C	Littorina littorea	KCl
290	-	enzyme from hepatopancreas, 24 h anoxic conditions, pH 7.5, 22°C	Littorina littorea	NaCl
300	-	enzyme from foot muscle, 24 h anoxic conditions, pH 7.5, 22°C	Littorina littorea	NaCl
990	-	enzyme from foot muscle, 24 h anoxic conditions, pH 7.5, 22°C	Littorina littorea	Urea
1170	-	enzyme from foot muscle, pH 7.5, 22°C	Littorina littorea	Urea
1310	-	enzyme from hepatopancreas, 24 h anoxic conditions, pH 7.5, 22°C	Littorina littorea	Urea
1490	-	enzyme from hepatopancreas, pH 7.5, 22°C	Littorina littorea	Urea

General Information

General Information	Comment	Organism
physiological function	dephosphorylation and activation of hepatopancreas hexokinase during anoxia may allow for increased shunting of glucose-6-phosphate into the pentose phosphate pathway, thereby producing reducing equivalents of NADPH. The activation of endogenous protein kinase C and AMP-activated protein kinase increase the Km for glucose for anoxic hepatopancreas hexokinase to a value that is similar to the control Km for glucose. Stimulation of endogenous protein kinase C, protein kinase G, and Calcium/calmodulin activated protein kinase for foot muscle hexokinase increase the Km for ATP to a value similar to that seen for the anoxic enzyme form. In both tissues, activation of endogenous phosphatases reverses the effects of protein kinases	Littorina littorea

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Release 2023.1 (January 2023)