Literature summary for 2.7.1.1 extracted from

Mergenthaler, P.; Kahl, A.; Kamitz, A.; van Laak, V.; Stohlmann, K.; Thomsen, S.; Klawitter, H.; Przesdzing, I.; Neeb, L.; Freyer, D.; Priller, J.; Collins, T.J.; Megow, D.; Dirnagl, U.; Andrews, D.W.; Meisel, A.
Mitochondrial hexokinase II (HKII) and phosphoprotein enriched in astrocytes (PEA15) form a molecular switch governing cellular fate depending on the metabolic state (2012), Proc. Natl. Acad. Sci. USA, 109, 1518-1523.

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Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
cerebral cortex	-	Rattus norvegicus	-

Synonyms

Synonyms	Comment	Organism
hexokinase II	-	Rattus norvegicus
HKII	-	Rattus norvegicus

General Information

General Information	Comment	Organism
malfunction	hypoxia-inducible factor (HIF)-1-regulated glycolytic enzyme hexokinase II (HKII) acts as a molecular switch that determines cellular fate by regulating both cytoprotection and induction of apoptosis based on the metabolic state. Together with phosphoprotein enriched in astrocytes (PEA15), HKII inhibits apoptosis after hypoxia. In contrast, HKII accelerates apoptosis in the absence of PEA15 and under glucose deprivation	Rattus norvegicus

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Release 2023.1 (January 2023)